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Sport Science Review

The Journal of National Institute for Sport Research

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2069-7244
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ACE I/D Polymorphism Determination in Turkish Elite Wind-surfers

Korkut Ulucan
  • Corresponding author
  • Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Üsküdar University, Turkey
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/ Seben Göle
Published Online: 2014-05-17 | DOI: https://doi.org/10.2478/ssr-2014-0005

Abstract

Insertion/ deletion (I/D) genetic polymorphism of the angiotensin converting enzyme I gene (ACE) represents the first and the most investigated genetic indicator of athletic performance in humans. In this report, we aimed to analyze the distribution of ACE I/D polymorphism in elite Turkish wind- surfers. DNA samples from the surfers were isolated from peripheral blood and standard PCR application was carried out in order to genotype the polymorphism. Of the 8 surfers (5 males and 3 females), 3 had I/I genotype (2 males and 1 female), 4 had I/D (2 males and females) and 1 was D/D (female). Direct allelic count revealed the I allele as 10 and D allele as 6 in our study cohort. According to our results, I allele was counted more than D allele, which is in agreement with the previous studies, indicating the importance of I allele in predisposition to endurance activities. We conclude that determining ACE I/D polymorphism will be a good biomarker in the terms of predisposition to certain kind of sports. However, these results must be extended with further studies in order to have more precise information about the effect of ACE I/D polymorphism on human performance.

Keywords: ACE; sports; Turkish; wind surfers

References

  • Álvarez, R., Terrados, N., Ortolano, R., & et al. (2000). Genetic variation in the renin-angiotensin system and athletic performance. Eur J Appl Physiol, 82, 117-20.Google Scholar

  • Amir, O., Amir, R., Yamin, C., Attias, E., Eynon, N., Sagiv, M., Sagiv, M., & Meckel, Y. (2007). The ACE deletion allele is associated with Israeli elite endurance athletes. Exp Physiol, 92, 881-6.Web of ScienceGoogle Scholar

  • Cam, F.S., Colakoglu, M., Sekuri, C., Colakoglu, S., Sahan, Ç., Berdeli, A. (2005). Association between the ACE I/D gene polymorphism and physical performance in a homogenous non-elite cohort. Can J Appl Physiol, 30, 74-86.CrossrefGoogle Scholar

  • Cieszczyk, P., Maciejewska, A., Sawczuk, M., Ficek, K., Eider, J., & Jascaniene, N. (2010). The angiotensin converting enzyme gene i/d polymorphism in ellite polish and lithuanian judo players. Biol Sport, 27, 119-22.CrossrefGoogle Scholar

  • Collins, E., Xenophontos, S. L., Cariolou, M. A., et al. (2004). The ACE gene and endurance performance during the South African Ironman triathlons. Med Sci Sport Exercise, 36, 1314-20.Google Scholar

  • Costa, M. F., & Slocombe, R. (2012). The Use of Angiotensin-I Converting Enzyme I/D Genetic Polymorphism as a Biomarker of Athletic Performance in Humans. Biosensors, 2, 396-404.CrossrefGoogle Scholar

  • Fatini, C., Guazzelli, R., Manetti, P., et al. (2000). RAS genes influence exerciseinduced left ventricular hypertrophy: An elite athletes study. Med Sci Sport Exercise, 32, 1868-72.CrossrefGoogle Scholar

  • Gayagay, G., Yu, B., Hambly, B., Boston, T., Hahn, A. Celermajer, D. S., & Trent, R. J. (1998). Elite endurance athletes and the ACE I allele- the role of genes in athletic performance. Hum Genet, 103, 48-50.Google Scholar

  • Holdys, J., Krysciak, J., Stanislawski, D., & Gronek, P. (2001). ACE I/D gene polymorphism in athletes of various sports disciplines. Human Movement, 12 (3), 223-31.Google Scholar

  • Montgomery, H. E., Clarkson, P., Dollery, C. M., et al. (1997). Association of Angiotensin-converting enzyme gene I/D polymorphism with chance in left ventricular mass in responsible to physical training. Circulation, 96, 741-7.Google Scholar

  • Montgomery, H., Marshall, R., Myerson, S., et al. (1998). Human gene for physical performance. Nature, 393, 221-2.Google Scholar

  • Myerson, S., Hamingway, H., Budget, R., Martin, J., Humphries, S., & Montgomery, H. (1999). Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol, 87, 1313-16.PubMedGoogle Scholar

  • Nagashima, J., Musha, H., Takada, H., Awaya, T., Oba, H., Mori, N., Ohmiya, K., Nobuoka, S., & Murayama, M. (2000). Influence of angiotensin-converting enzyme gene polymorphism on development of athlete’s heart. Clin Cardiol, 23, 621-4.CrossrefGoogle Scholar

  • Ulucan, K., & Göle, S. (2013). Preliminary Findings of α -Actinin-3 Gene Distribution in Elite Turkish Wind Surfers. Balkan J Med Genet, 16(1), 69-72. Woods, D. R., Humphries, S. E., Montgomery, H. E. (2003). The ACE I/D polymorphism and human physical performance. Trends Endocrinol Metab, 11, 416-20.Google Scholar

  • Woods, D., Hickman, M., Jamshidi, Y., Brull, D., Vassiliou, V., Jones, A., Humphries, S., & Montgomery, H. (2001). Elite swimmers and the D allele of the ACE I/D polymorphism. Hum Genet, 108, 230-2.Google Scholar

  • Zhang, B., Tanaka, H., Shono, N., Miura, S., Kiyonaga, A., Shindo, M., & Saku, K. (2003). The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle. Clin Genet, 63, 139-44. Google Scholar

About the article

Published Online: 2014-05-17

Published in Print: 2014-04-01


Citation Information: Sport Science Review, ISSN (Online) 2069-7244, ISSN (Print) 2066-8732, DOI: https://doi.org/10.2478/ssr-2014-0005.

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© by Korkut Ulucan. This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. BY-NC-ND 3.0

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