Jump to ContentJump to Main Navigation
Show Summary Details
More options …

tm - Technisches Messen

Plattform für Methoden, Systeme und Anwendungen der Messtechnik

[TM - Technical Measurement: A Platform for Methods, Systems, and Applications of Measurement Technology
]

Editor-in-Chief: Puente León, Fernando / Zagar, Bernhard


IMPACT FACTOR 2018: 0.594

CiteScore 2018: 0.54

SCImago Journal Rank (SJR) 2018: 0.261
Source Normalized Impact per Paper (SNIP) 2018: 0.563

Online
ISSN
2196-7113
See all formats and pricing
More options …
Volume 82, Issue 6

Issues

Metrology-based quality and process control in automated stem cell production

Messtechnikbasierte Qualitätskontrolle und Prozesssteuerung in der automatisierten Stammzellproduktion

Friedrich W. Schenk / Michael Kulik / Robert Schmitt
Published Online: 2015-06-08 | DOI: https://doi.org/10.1515/teme-2015-0036

Abstract

We present a fully automated production platform for the generation, cultivation and differentiation of induced pluripotent stem cells. Cell culture, the process by which cells are grown outside of their natural environment, is a highly individual process. It can only be performed automatically by employing specialized metrology in combination with adaptive process control. A main motivation for automated versus manually assisted cell production is the increase in throughput and quality. Therefore all devices in the production platform have to be high-throughput capable and deliver reproducible results. Especially by combining high-speed microscopy with intelligent automation, a metrology-based quality and process control could be realized which allows the production of iPS cells on an industrial scale for the first time.

Zusammenfassung

In dem vorliegenden Artikel wird eine vollständig automatisierte Produktionseinheit zur Generierung, Kultivierung und Differenzierung induziert pluripotenter Stammzellen vorgestellt. Das Kultivieren von Zellen außerhalb ihres Organismus, die sogenannte Zellkultur, ist ein sehr individuell ablaufender Prozess. Ihn zu automatisieren erfordert hochspezialisierte Messtechnik in Verbindung mit einer adaptiven Prozesssteuerung. Ein Hauptziel der automatisierten im Gegensatz zur manuell assistierten Zellproduktion liegt in der Steigerung des Durchsatzes sowie der Qualität der produzierten Zellen. Dementsprechend müssen alle Geräte und vor allem die Messtechnik, die in einer solchen Produktionseinheit zum Einsatz kommt, hochdurchsatzfähig und sehr zuverlässig sein. Insbesondere dank eines eigens entwickelten Hochdurchsatz-Mikroskopieverfahrens konnte eine messtechnikbasierte Qualitätskontrolle und Prozesssteuerung für die Produktion von iPS-Zellen in industriellem Maßstab realisiert werden.

Keywords: Microscopy; automation; process control

Schlagwörter: Mikroskopie; Automatisierungstechnik; Prozesssteuerung

About the article

Friedrich W. Schenk

Friedrich Walter Schenk studied Electrical Engineering and Information Technology at TU Darmstadt, Telecom ParisTech and RWTH Aachen University from 2004 to 2010. In 2011 he finished his postgraduate studies in economics at RWTH Aachen. From 2011 on he is research associate at the Fraunhofer Institute for Production Technology IPT in the department of Production Metrology. His focus of work is in the field of life sciences metrology especially high throughput microscopy.

Fraunhofer Institute for Production Technology IPT, Production Metrology, Steinbachstr. 17, Aachen

Michael Kulik

Michael Kulik studied Mechanical Engineering at RWTH Aachen from 2006 to 2012. From 2012 on he is research associate at the Fraunhofer Institute for Production Technology IPT in the department of Production Metrology. His focus of work is in the field of life sciences automation especially in control software development for automated production platforms.

Fraunhofer Institute for Production Technology IPT, Production Metrology, Steinbachstr. 17, Aachen

Robert Schmitt

Robert Schmitt is head of Chair of Metrology and Quality Management and member of the board of directors for the Laboratory for Machine Tools and Production Engineering WZL of the RWTH Aachen University. He is also head of the department Production Metrology and Quality of the Fraunhofer Institute for Production Technology IPT as well as member of the board of directors of the Fraunhofer IPT.

University Aachen, Fertigungsmesstechnik, Steinbachstraße 19, Aachen


Accepted: 2015-05-11

Received: 2015-04-20

Published Online: 2015-06-08

Published in Print: 2015-06-28


Citation Information: tm - Technisches Messen, Volume 82, Issue 6, Pages 309–316, ISSN (Online) 2196-7113, ISSN (Print) 0171-8096, DOI: https://doi.org/10.1515/teme-2015-0036.

Export Citation

©2015 Walter de Gruyter Berlin/Boston.Get Permission

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Maciej Daniszewski, Duncan E. Crombie, Rachael Henderson, Helena H. Liang, Raymond C. B. Wong, Alex W. Hewitt, and Alice Pébay
SLAS TECHNOLOGY: Translating Life Sciences Innovation, 2017, Page 247263031771222
[2]
Friedrich Walter Schenk, Nicolai Brill, Ulrich Marx, Daniel Hardt, Niels König, and Robert Schmitt
Scientific Reports, 2016, Volume 6, Number 1

Comments (0)

Please log in or register to comment.
Log in