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tm - Technisches Messen

Plattform für Methoden, Systeme und Anwendungen der Messtechnik

[TM - Technical Measurement: A Platform for Methods, Systems, and Applications of Measurement Technology
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Editor-in-Chief: Puente León, Fernando / Zagar, Bernhard


IMPACT FACTOR 2017: 0.476

CiteScore 2017: 0.46

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2196-7113
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Volume 85, Issue 5

Issues

Development of bioimpedance sensing device for wearable monitoring of the aortic blood pressure curve

Entwicklung eines Bioimpedanz-Messgerätes für die mobile Erfassung des aortalen Blutdruck

H. Kõiv / M. Rist / M. Min
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  • 54561 Tallinn University of Technology, Thomas Johann Seebeck Department of Electronics, Tallinn, Estonia
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Published Online: 2018-03-27 | DOI: https://doi.org/10.1515/teme-2017-0113

Abstract

Wearable devices that monitor our vital signs have been gaining more importance with each year. Non-invasive, continuous, accurate and precise blood pressure assessment method integrated in a wearable is a multidisciplinary challenge. This work presents an electrical bioimpedance (EBI) unit for multi-frequency measurements on pulsating artery for central aortic pressure (CAP) estimation. The developed device provides low complexity in the electronics design with a frequency range between 1 kHz and 200 kHz. It is able to register the impedance of blood vessel volume change simultaneously at different locations. Experiments were carried out in vivo by using the four-electrode configuration on human thorax, axillary artery and radial artery. Preliminary results show the applicability of the proposed impedance spectroscopy system to measure blood vessel volume changes. The impedance data can be later interpreted into the aortic blood pressure wave by using a generalized transfer function. In addition, experimental test-phantom and electrode design are introduced for testing purposes of the impedance system.

Zusammenfassung

Tragbare Messgeräte, welche unsere Vitalfunktionen aufzeichnen, gewinnen von Jahr zu Jahr an Bedeutung. Nicht-invasive, kontinuierliche, präzise und genaue Blutdruckmessverfahren, welche in einem tragbaren System realisiert werden, sind eine multidisziplinäre Herausforderung. Diese Arbeit präsentiert ein Messgerät, welches die elektrische Bioimpedanz (EBI) einer pulsierenden Arterie misst, um den zentralen aortalen Blutdruck (CAP) zu bestimmen. Das entwickelte Gerät basiert auf einem einfachen elektrischen Design und deckt einen Frequenzbereich zwischen 1 kHz und 200 kHz ab. Es ermöglicht die simultane Erfassung der Volumenänderung einer Arterie an mehreren Messpunkten. Die Experimente wurden in vivo mit einer Konfiguration aus vier Elektroden an einem menschlichen Thorax, Arteria axillaris und der Arteria radialis durchgeführt. Zwischenergebnisse zeigen die grundsätzliche Anwendbarkeit der Impedanzspektroskopie, welche die Volumenänderung der Blutgefäße erfasst. Die Daten der Impedanzmessung werden mittels einer generalisierenden Transferfunktion in arterielle Blutdruckkurven umgewandelt. Des Weiteren zeigen wir ein experimentelles Phantom und das Elektrodendesign für Testzwecke des Bioimpedanzsystems.

Keywords: Hypertension; aortic blood pressure; electrical bioimpedance; impedance spectroscopy; wearable; gelatine phantom

Schlagwörter: Arterielle Hypertonie; Bluthochdruck; elektrische Bioimpedanz; tragbare Impedanzspektroskopie; Gelatine-Phantom

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About the article

H. Kõiv

Hip Kõiv was born in Kanepi, Estonia in 1990. She received the B. S. degree in electronics and bionics in 2013 and the M. S. degree in electronics and communication in 2015 from Tallinn University of Technology. She is currently pursuing the Ph. D. degree in Thomas Johann Seebeck Department of Electronics at Tallinn University of Technology and her current research interests include the bioimpedance study, aortic blood pressure measurements and the materials for developing biological phantoms.

M. Rist

Marek Rist was born in Tallinn, Estonia, in 1980. He received the M. Sc. degree in electronics and biomedical engineering in 2007, in Tallinn University of Technology, Tallinn, Estonia with a thesis on technology for measurement of impedance of lithium-ion batteries. He is currently pursuing the Ph. D. degree in electronics engineering in Tallinn University of Technology where he is involved in several projects related to electrical impedance spectroscopy.

M. Min

Mart Min (M’95–SM’13) received the Diploma Engineer’s qualification in electronics from Tallinn University of Technology (TUT), Estonia, in 1969 and the Ph. D. degree in measurement science from Kiev Polytechnic, Ukraine, in 1984. He has been with Thomas Johann Seebeck Department of Electronics of the TUT as a Professor and a Leading Scientist since 1992. During 1992–1993, he was with the Technical University of Munich and the Bundeswehr University in Munich, Germany, as a Guest Scientist and a Professor. During 2007–2010, he joined the Institute of Bioprocessing and Analytical Measurement Technique in Heilbad Heiligenstadt, Germany. He is interested in measurement and processing of bio-signals with implementations in industry, including developing of pacemakers for the companies St. Jude Medical (USA/Sweden) and Guidant/Cardiac Pacemakers (USA). He is a member of Instrumentation & Measurement and Engineering in Biology and Medicine Societies of the IEEE. Prof. Min belongs to the International Committee for Promotion of Research in Bio-Impedance (ICPRBI).


Received: 2017-09-15

Revised: 2018-01-20

Accepted: 2018-03-18

Published Online: 2018-03-27

Published in Print: 2018-05-25


Funding Source: Eesti Teadusagentuur

Award identifier / Grant number: IUT19-11

The research was supported by Eesti Teadusagentuur (grant IUT19-11) and the Centre of ICT Research Excellence EXCITE in collaboration with the Horizon 2020 Framework Programme FLAG-ERA JTC 2016 HESN project CONVERGENCE.


Citation Information: tm - Technisches Messen, Volume 85, Issue 5, Pages 366–377, ISSN (Online) 2196-7113, ISSN (Print) 0171-8096, DOI: https://doi.org/10.1515/teme-2017-0113.

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