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tm - Technisches Messen

Plattform für Methoden, Systeme und Anwendungen der Messtechnik

[TM - Technical Measurement: A Platform for Methods, Systems, and Applications of Measurement Technology

Editor-in-Chief: Puente León, Fernando / Zagar, Bernhard

IMPACT FACTOR 2017: 0.476

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Volume 85, Issue 5


Development of bioimpedance sensing device for wearable monitoring of the aortic blood pressure curve

Entwicklung eines Bioimpedanz-Messgerätes für die mobile Erfassung des aortalen Blutdruck

H. Kõiv / M. Rist / M. Min
  • Corresponding author
  • 54561 Tallinn University of Technology, Thomas Johann Seebeck Department of Electronics, Tallinn, Estonia
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Published Online: 2018-03-27 | DOI: https://doi.org/10.1515/teme-2017-0113


Wearable devices that monitor our vital signs have been gaining more importance with each year. Non-invasive, continuous, accurate and precise blood pressure assessment method integrated in a wearable is a multidisciplinary challenge. This work presents an electrical bioimpedance (EBI) unit for multi-frequency measurements on pulsating artery for central aortic pressure (CAP) estimation. The developed device provides low complexity in the electronics design with a frequency range between 1 kHz and 200 kHz. It is able to register the impedance of blood vessel volume change simultaneously at different locations. Experiments were carried out in vivo by using the four-electrode configuration on human thorax, axillary artery and radial artery. Preliminary results show the applicability of the proposed impedance spectroscopy system to measure blood vessel volume changes. The impedance data can be later interpreted into the aortic blood pressure wave by using a generalized transfer function. In addition, experimental test-phantom and electrode design are introduced for testing purposes of the impedance system.


Tragbare Messgeräte, welche unsere Vitalfunktionen aufzeichnen, gewinnen von Jahr zu Jahr an Bedeutung. Nicht-invasive, kontinuierliche, präzise und genaue Blutdruckmessverfahren, welche in einem tragbaren System realisiert werden, sind eine multidisziplinäre Herausforderung. Diese Arbeit präsentiert ein Messgerät, welches die elektrische Bioimpedanz (EBI) einer pulsierenden Arterie misst, um den zentralen aortalen Blutdruck (CAP) zu bestimmen. Das entwickelte Gerät basiert auf einem einfachen elektrischen Design und deckt einen Frequenzbereich zwischen 1 kHz und 200 kHz ab. Es ermöglicht die simultane Erfassung der Volumenänderung einer Arterie an mehreren Messpunkten. Die Experimente wurden in vivo mit einer Konfiguration aus vier Elektroden an einem menschlichen Thorax, Arteria axillaris und der Arteria radialis durchgeführt. Zwischenergebnisse zeigen die grundsätzliche Anwendbarkeit der Impedanzspektroskopie, welche die Volumenänderung der Blutgefäße erfasst. Die Daten der Impedanzmessung werden mittels einer generalisierenden Transferfunktion in arterielle Blutdruckkurven umgewandelt. Des Weiteren zeigen wir ein experimentelles Phantom und das Elektrodendesign für Testzwecke des Bioimpedanzsystems.

Keywords: Hypertension; aortic blood pressure; electrical bioimpedance; impedance spectroscopy; wearable; gelatine phantom

Schlagwörter: Arterielle Hypertonie; Bluthochdruck; elektrische Bioimpedanz; tragbare Impedanzspektroskopie; Gelatine-Phantom


  • 1.

    ESC, “European cardiovascular disease statistics 2017 edition, ” Tech. Rep., 2017.

  • 2.

    “High Blood Pressure (Hypertension) Information | cdc.gov,” Cdc.gov, 2017 [Online]. Available: https://www.cdc.gov/bloodpressure/index.htm [Accessed: 10-Sep-2017].Google Scholar

  • 3.

    C. M. McEniery, J. R. Cockcroft, M. J. Roman, S. S. Franklin and I. B. Wilkinson, “Central blood pressure: current evidence and clinical importance,” Eur. Heart J., vol. 35, no. 26, pp. 1719–1725, Jul. 2014.Web of ScienceGoogle Scholar

  • 4.

    B. Freeman and J. Berger, Anesthesiology Core Review: Part 2, Chapter 1: Invasive Arterial Blood Pressure Monitoring, Cenveo® Publisher Services, 2016.Google Scholar

  • 5.

    A. Avolio, M. Butlin, and A. Walsh, “Arterial blood pressure measurement and pulse wave analysis – their role in enhancing cardiovascular assessment,” Physiological Measurement, vol. 31, no. 1, pp. R1–R47, 2009.Google Scholar

  • 6.

    L. Nainggolan, “New Devices to Measure Central Aortic Pressure: Interesting But Premature,” Medscape, 2011.

  • 7.

    S. DeLoach and R. Townsend, “Vascular Stiffness: Its Measurement and Significance for Epidemiologic and Outcome Studies,” Clinical Journal of the American Society of Nephrology, vol. 3, no. 1, pp. 184–192, 2008.Web of ScienceCrossrefGoogle Scholar

  • 8.

    A. Krivoshei, J. Lamp, M. Min, T. Uuetoa, H. Uuetoa and P. Annus, “Non-invasive method for the aortic blood pressure waveform estimation using the measured radial EBI,” Journal of Physics: Conference Series, vol. 434, 012048, 2013.Google Scholar

  • 9.

    “Home – HealthSTATS,” Healthstats.com, 2017 [Online]. Available: http://www.healthstats.com/index3.php?page=product_bppro_intro [Accessed: 3-Feb-2017].Google Scholar

  • 10.

    “Tensys Medical – cetrixtablets,” cetrixtablets, 2018 [Online]. Available: http://www.cetrixtablets.com/project-details/tensys-medical/ [Accessed: 10-Jan-2018].Google Scholar

  • 11.

    O. monitor, “Omron HEM-9000AI blood pressure mon,” Medi-Shop, 2018 [Online]. Available: http://www.medi-shop.gr/en/patient-monitors/omron-hem-9000ai [Accessed: 07-Jan-2018].Google Scholar

  • 12.

    “The intelligent pressure monitoring system, CODAN, Xtrans, Brochure” [Online]. Available: https://www.codan.de/documents/website/GB/CODAN_Xtrans_GB.pdf [Accessed: 3-Nov-2017].Google Scholar

  • 13.

    A. Krivošei, H. Uuetoa, M. Min, P. Annus, T. Uuetoa and J. Lamp, “Adaptive Algorithm for Cardiac Period Normalization in Time,” in Book of Abstracts: 16th International Conference on Electrical Bio-Impedance (ICEBI) and the 17th Conference on Electrical Impedance Tomography (EIT) 2016, pp. 66, 2016.Google Scholar

  • 14.

    A. Krivošei, M. Min, P. Annus, H. Kõiv, A. Aabloo and T. Uuetoa, “Analysis of Instantaneous Cardiac EBI Signal Variability over the Heart Cycle(s): Non-Linear Time-Scale Approach,” in Joint Conference of European Medical and Biological Engineering Conference (EMBEC) and Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC) (EMBEC2017), Tampere, Finland, pp. 940–943, 2017.Google Scholar

  • 15.

    A. Cömert and J. Hyttinen, “Investigating the possible effect of electrode support structure on motion artifact in wearable bioelectric signal monitoring,” BioMedical Engineering OnLine, vol. 14, no. 1, 2015.Web of ScienceGoogle Scholar

  • 16.

    M. Min, A. Krivošei, P. Annus, H. Kõiv, T. Uuetoa and J. Lamp, “Bioimpedance sensing – a viable alternative for tonometry in non-invasive assessment of central blood pressure”, in Proc. 12th Annual IEEE International Symposium on Medical Measurements and Applications (MeMeA, Mayo Clinic, Rochester, MN, USA), IEEE, pp. 373–378, 2017, DOI:.CrossrefGoogle Scholar

  • 17.

    A. T. Mobashsher and A.M. Abbosh, “Artificial Human Phantoms: Human Proxy in Testing Microwave Apparatuses That Have Electromagnetic Interaction with the Human Body,” IEEE Microwave Magazine, vol. 16, no. 6, 2015.Google Scholar

  • 18.

    T. K. Bera, “Bioelectrical Impedance Methods for Noninvasive Health Monitoring: A review,” Journal of Medical Engineering, vol. 2014, Article ID 381251, 28 pages, 2014.Google Scholar

  • 19.

    C. Gabriel, S. Gabriel and E. Corthout, “The dielectric properties of biological tissues: I. Literature survey,” Physics in Medicine and Biology, vol. 41, no. 11, pp. 2231–2249, 1996.CrossrefGoogle Scholar

  • 20.

    A. Pinto, P. Bertemes-Filho and A. Paterno, “Gelatin: a skin phantom for bioimpedance spectroscopy,” Biomedical Physics & Engineering Express, vol. 1, no. 3, 035001, 2015.Web of ScienceGoogle Scholar

  • 21.

    A. K. Dabrowska, G.-M. Rotaru, S. Derler, F. Spano, M. Camenzind, S. Annaheim, R. Stämpfli, M. Schmid and R. M. Rossi, “Materials used to simulate physical properties of human skin,” Skin Research and Technology, vol. 22, pp. 3–14, 2016.Web of ScienceCrossrefGoogle Scholar

  • 22.

    A. Katihabwa, W. Wang, Y. Jiang, X. Zhao, Y. Lu and L. Zhang, “Multi-walled carbon nanotubes/silicone rubber nanocomposites prepared by high shear mechanical mixing,” Journal of Reinforced Plastics and Composites, vol. 30, no. 12, pp. 1007–1014, 2011.CrossrefWeb of ScienceGoogle Scholar

  • 23.

    A. Saleem, L. Frormann and A. Soever, “Fabrication of Extrinsically Conductive Silicone Rubbers with High Elasticity and Analysis of Their Mechanical and Electrical Characteristics,” Polymers, vol. 2, no. 3, pp. 200–210, 2010.CrossrefWeb of ScienceGoogle Scholar

  • 24.

    B. Mensah, H. Kim, J. Lee, S. Arepalli and C. Nah, “Carbon nanotube-reinforced elastomeric nanocomposites: a review,” International Journal of Smart and Nano Materials, vol. 6, no. 4, pp. 211–238, 2015.CrossrefWeb of ScienceGoogle Scholar

  • 25.

    S. Grimnes and Ø. G. Martinsen, Bioimpedance and bioelectricity basics, Academic Press, 2000.Google Scholar

  • 26.

    R. Land, P. Annus, M. Min, et al.Method and device for broadband analysis of systems and substances. European Patent Application EP2565654A2, Bulletin 2013/10; US Application US2013054178A1, publ. Feb. 28, 2013. – Patent.

  • 27.

    M. Rist, M. Reidla, M. Min, T. Parve, O. Märtens and R. Land, “TMS320F28069-based impedance spectroscopy with binary excitation,” in EDERC 2012 Proceedings of the 5th European DSP in Education & Research Conference, pp. 217–220, 2012.Google Scholar

  • 28.

    S. Halonen, K. Annala, J. Kari, S. Jokinen, A. Lumme, K. Kronström and A. Yli-Hankala, “Detection of spine structures with Bioimpedance Probe (BIP),” Journal of Clinical Monitoring and Computing, pp. 1–8, 2016.Web of ScienceGoogle Scholar

  • 29.

    IEC 60601 – TC 62/SC 62A – Common aspects of electrical equipment used in medical practice. International Standard, Edition 1.0, 2015.

  • 30.

    J. Schneider, M. Schroth, M. Holzhey, T. Blocher and W. Stork, “An approach to improve impedance plethysmography on the wrist by using adaptive feedback control,” in 2017 IEEE Sensors Applications Symposium (SAS), 2017.Google Scholar

  • 31.

    J. Wang, W. Hu, T. Kao, C. Liu and S. Lin, “Development of forearm impedance plethysmography for the minimally invasive monitoring of cardiac pumping function,” Journal of Biomedical Science and Engineering, vol. 04, no. 02, pp. 122–129, 2011.CrossrefGoogle Scholar

  • 32.

    J. Xu, X. Gao, A. Lee, S. Yamada, E. Yavari, V. Lubecke and O. Boric-Lubecke, “Wrist-worn heartbeat monitoring system based on bio-impedance analysis,” in 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2016.Google Scholar

  • 33.

    B. Han, Y. Xu and F. Dong, “Design of current source for multi-frequency simultaneous electrical impedance tomography,” Review of Scientific Instruments, vol. 88, no. 9, 094709, 2017.Web of ScienceGoogle Scholar

  • 34.

    B. Sanchez, E. Louarroudi and R. Pintelon, “Time-invariant measurement of time-varying bioimpedance using vector impedance analysis,” Physiological Measurement, vol. 36, no. 3, pp. 595–620, 2015.CrossrefWeb of ScienceGoogle Scholar

About the article

H. Kõiv

Hip Kõiv was born in Kanepi, Estonia in 1990. She received the B. S. degree in electronics and bionics in 2013 and the M. S. degree in electronics and communication in 2015 from Tallinn University of Technology. She is currently pursuing the Ph. D. degree in Thomas Johann Seebeck Department of Electronics at Tallinn University of Technology and her current research interests include the bioimpedance study, aortic blood pressure measurements and the materials for developing biological phantoms.

M. Rist

Marek Rist was born in Tallinn, Estonia, in 1980. He received the M. Sc. degree in electronics and biomedical engineering in 2007, in Tallinn University of Technology, Tallinn, Estonia with a thesis on technology for measurement of impedance of lithium-ion batteries. He is currently pursuing the Ph. D. degree in electronics engineering in Tallinn University of Technology where he is involved in several projects related to electrical impedance spectroscopy.

M. Min

Mart Min (M’95–SM’13) received the Diploma Engineer’s qualification in electronics from Tallinn University of Technology (TUT), Estonia, in 1969 and the Ph. D. degree in measurement science from Kiev Polytechnic, Ukraine, in 1984. He has been with Thomas Johann Seebeck Department of Electronics of the TUT as a Professor and a Leading Scientist since 1992. During 1992–1993, he was with the Technical University of Munich and the Bundeswehr University in Munich, Germany, as a Guest Scientist and a Professor. During 2007–2010, he joined the Institute of Bioprocessing and Analytical Measurement Technique in Heilbad Heiligenstadt, Germany. He is interested in measurement and processing of bio-signals with implementations in industry, including developing of pacemakers for the companies St. Jude Medical (USA/Sweden) and Guidant/Cardiac Pacemakers (USA). He is a member of Instrumentation & Measurement and Engineering in Biology and Medicine Societies of the IEEE. Prof. Min belongs to the International Committee for Promotion of Research in Bio-Impedance (ICPRBI).

Received: 2017-09-15

Revised: 2018-01-20

Accepted: 2018-03-18

Published Online: 2018-03-27

Published in Print: 2018-05-25

Funding Source: Eesti Teadusagentuur

Award identifier / Grant number: IUT19-11

The research was supported by Eesti Teadusagentuur (grant IUT19-11) and the Centre of ICT Research Excellence EXCITE in collaboration with the Horizon 2020 Framework Programme FLAG-ERA JTC 2016 HESN project CONVERGENCE.

Citation Information: tm - Technisches Messen, Volume 85, Issue 5, Pages 366–377, ISSN (Online) 2196-7113, ISSN (Print) 0171-8096, DOI: https://doi.org/10.1515/teme-2017-0113.

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