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Turkish Journal of Biochemistry

Türk Biyokimya Dergisi


IMPACT FACTOR 2018: 0.329

CiteScore 2018: 0.28

SCImago Journal Rank (SJR) 2018: 0.138
Source Normalized Impact per Paper (SNIP) 2018: 0.169

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1303-829X
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Volume 41, Issue 3

Issues

Hypoglycemic and hypolipidemic effects of Caralluma tuberculata and its safety on liver and kidneys of diabetic rats / Diyabetik sıçanların karaciğer ve böbrekleri üzerinde Caralluma tuberculata’nın hipoglisemik ve hipolipidemik etkisi ve güvenliği

Jafar Poodineh / Alireza Nakhaee
  • Corresponding author
  • Zahedan University of Medical Sciences, Faculty of Medicine, Department of Clinical Biochemistry, Zahedan, Iran
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Published Online: 2016-06-01 | DOI: https://doi.org/10.1515/tjb-2016-0023

Abstract

Objective: Caralluma tuberculata is a succulent plant that grows in some regions of Baluchestan province in Iran, and is widely used by natives as antidiabetic agent. This study evaluates the antidiabetic effects of aerial part suspension of Caralluma tuberculata (SCT) at two doses of 100 and 200 mg/kg and its safety on liver and kidneys of Streptozotocin (STZ)-induced diabetic rats.

Methods: Diabetes was rendered via single dose of STZ (60 mg/kg, injected intraperitoneally). Forty eight rats were classified into 6 groups as follow; (I): Normal control, (II): Normal + SCT (200 mg/kg), (III): STZ Diabetic, (IV): STZ + vehicle, (V): STZ + SCT (100 mg/kg), (VI) STZ + SCT (200 mg/kg). The effects of 45 days of treatment with the SCT on oral glucose tolerance test (OGTT), lipid profile, hematological and biochemical parameters evaluated.

Results: SCT treated groups exhibited a significant (p<0.05) improvement in abnormalities of OGTT, biochemical and hematological parameters compared with the diabetic control group. Furthermore, SCT at both doses, returned significantly (p<0.01) diabetes-induced changes in lipid profile except HDL-C levels that only, were significantly (p<0.05) increased at dose of 200 mg/kg. There was no significant difference in hematological, liver and kidney parameters between normal control and normal animals receiving SCT.

Conclusion: The present results revealed that Caralluma tuberculata could be beneficial for amending hyperglycemia, hyperlipidemia, and hematological changes induced by diabetes. It may also protect the liver and kidneys against complications caused by diabetes without any toxic effects.

Ozet

Amac: Caralluma tuberculata İran’ın Belucistan bolgesinde yetişen, lezzetli bir bitkidir ve yaygın olarak yerliler tarafından anti-diyabetik olarak kullanılmaktadır. Bu calışmada, Caralluma tuberculata (SCT)’nın antenlerinden elde edilen suspansiyonun 100 ve 200 mg/kg lık dozlarda Streptozotocin (STZ) ile induklenmiş diyabetik sıcanlarda kullanımı ve karaciğer ve bobrekler uzerindeki guvenliği incelenmiştir.

Metod: Sıcanlarda periton icine 60mg/kg STZ verilerek diyabet oluşturulmuştur. Kırk sekiz sıcan, (I): Normal control, (II): Normal + SCT (200 mg/kg), (III): STZ Diabetic, (IV): STZ + vehicle, (V): STZ + SCT (100 mg/kg), (VI) STZ + SCT (200 mg/kg) olmak uzere altı gruba ayrılmıştır. 45 gunluk SCT tedavisi surecinde glukoz toleransı (OGTT) lipid profilleri, kan ve biyokşmyasal parametreleri değerlendirilmiştir.

Bulgular: SCT ile tedavi edilen grupların, diyabetik kontrol grubuna gore, biyokimyasal ve kan parametreleri ile OGGT anomalilerinde belirgin bir (p<0.05) sağaltım gorulmuştur. Buna ek olarak, her iki doz SCT, HDL-C seviyeleri dışında, diyabete bağlı lipit profillerini duzeltmiştir (p<0.01). HDL-C seviyeleri 200 mg/kg dozunda belirgin bir şekilde (p<0.05) artış gostermiştir. Normal kontrollerde ve SCT almış normal hayvanların kan, karaciğer ve bobrek parametrlerinde belirgin bir fark bulunmamıştır.

Sonuc: Bu calışma sonuclarına gore Caralluma tuberculata, diayabete bağlı olarak değişen hiperglisemi, hiperlipidemi ve kan parametrelerindeki değişimleri duzenlemekte yararlıdır. Ayrıca diyabete bağlı olarak gelişen bobrek ve karaciğer komplikasyonlarına karşı da koruyucudur.

Keywords: Caralluma tuberculata; diabetes; hyperglycemia; oral glucose tolerance test; hyperlipidemia

Anahtar Kelimeler: Caralluma tuberculata; diyabet; hiperglisemi; oral glukoz tolerans testi; hiperlipidemi

About the article

Received: 2015-07-25

Accepted: 2015-12-22

Published Online: 2016-06-01

Published in Print: 2016-06-01


Citation Information: Turkish Journal of Biochemistry, Volume 41, Issue 3, Pages 136–143, ISSN (Online) 1303-829X, ISSN (Print) 0250-4685, DOI: https://doi.org/10.1515/tjb-2016-0023.

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