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Turkish Journal of Biochemistry

Türk Biyokimya Dergisi


IMPACT FACTOR 2018: 0.329

CiteScore 2018: 0.28

SCImago Journal Rank (SJR) 2018: 0.138
Source Normalized Impact per Paper (SNIP) 2018: 0.169

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1303-829X
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Band 41, Heft 6

Hefte

A rare cause of hyperamylasemia: multiple myeloma

Hiperamilazeminin Nadir Bir Nedeni: Multipl Myeloma

Gülden Sincan / Yusuf Bilen / Fuat Erdem / Mehmet Gündoğdu
Online erschienen: 14.10.2016 | DOI: https://doi.org/10.1515/tjb-2016-0152

Abstract

Background:

A higher amylase than normal concentration may reflect one of several medical conditions, including acute inflammation of the pancreas, perforated peptic ulcer, torsion of an ovarian cyst, strangulation ileus, mesenteric ischemia, macroamylasemia, renal failure and mumps. In addition; amylase production by epithelial carcinomas has been well documented. But hyperamylasemia associated with multiple myeloma has been reported only in a few cases. We report a case with hyperamylasemia associated with multiple myeloma in this paper because of rarity.

Case report:

We report a 64 year old male patient with multiple myeloma. He had hyperamylasemia and no evidence of pancreatic and salivary gland disease, renal failure. The patient had relapse disease after autologous bone marrow transplant. Amylase value is high correlated with his disease status. Combined chemotherapy (lenalidomide 25 mg once daily orally on days 1–21 and dexamethosone 40 mg/day, days 1–4 of repeated 28-day cycles) was started to our patient for multiple myeloma. The amylase level decresed to a normal level after 28 days.

Conclusion:

Paraneoplastic hyperamylasaemia as a marker to monitor disease progression and treatment response in cases with multiple myeloma. It related to extensive extra-medullary spread, extensive bone destruction and shorter survival time.

Özet

Giriş:

Normalden daha yüksek amilaz konsantrasyonu pankreasın akut inflamasyonu, perfore peptik ülser, over kist torsiyonu, strangüle ileus, mezenterik iskemi, makroamilazemi, böbrek yetmezliği ve kabakulak gibi tıbbi durumları yansıtabilir. Epitelyal kanserinden amilaz üretimi iyi dökümante edilmiştir. Fakat multipl myeloma ilişkili hiperamilazemi sadece birkaç vakada bildirilmiştir. Biz bu yazıda multipl myeloma ile ilişkili hiperamilazemili bir olguyu nadir görülmesi nedeniyle sunuyoruz.

Vaka sunumu:

Biz pankreatik ve tükrük bezi hastalığı bulgusu olmaksızın hiperamilazemisi olan multipl myelomalı 64 yaşındaki bir erkek olguyu sunuyoruz. Hasta otolog kök hücre nakli sonrası nüks olan hastalığa sahipti. Amilaz değeri hastanın hastalık durumu ile ilişkili olarak yüksekti. Hastaya multipl myeloma için kombine kemoterapi (lenalidomid 25 mg/gün D1-21 ve deksametazon 40 mg/gün D1-4 28 günde bir tekrarlanarak) başlandı. Amilaz değeri 28 gün sonra normal değerine geriledi.

Sonuç:

Multipl myelomalı olgularda paraneoplatik hiperamilazemi hastalık progresyonu ve tedaviye cevap monitorizasyonunda bir belirteçtir. Paraneoplastik hiperamilazemi aşırı ekstramedüller yayılım, yoğun kemik destrüksiyonu ve kısa yaşam süresiyle ilişkilidir.

Keywords: Hyperamylasemia; paraneoplastic; multiple myeloma

Anahtar kelimeler:: Hiperamilazemi; paraneoplastik; multipl myeloma

References

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Artikelinformationen

Erhalten: 11.10.2015

Angenommen: 13.04.2016

Online erschienen: 14.10.2016

Erschienen im Druck: 01.12.2016


Conflict of interest statement: Authors have no conflict of interest.


Quellenangabe: Turkish Journal of Biochemistry, Band 41, Heft 6, Seiten 479–481, ISSN (Online) 1303-829X, ISSN (Print) 0250-4685, DOI: https://doi.org/10.1515/tjb-2016-0152.

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