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Turkish Journal of Biochemistry

Türk Biyokimya Dergisi


IMPACT FACTOR 2018: 0.329

CiteScore 2018: 0.28

SCImago Journal Rank (SJR) 2018: 0.138
Source Normalized Impact per Paper (SNIP) 2018: 0.169

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1303-829X
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Volume 44, Issue 5

Issues

Fibrinopeptide-A and fibrinopeptide-B may help to D-dimer as early diagnosis markers for acute mesenteric ischemia

Fibrinopeptid-A ve Fibrinopeptid-B, Akut Mesenterik İskemi Erken Tanı Belirteçleri Olarak D-Dimere Yardımcı Olabilir

Murat Cikot
  • Corresponding author
  • Department of General Surgery, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
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  • De Gruyter OnlineGoogle Scholar
/ Eyup Gemici / Nilgun IsiksacanORCID iD: https://orcid.org/0000-0002-0230-6500 / Osman Kones / Pinar Kasapoglu / Sinan Binboga / Elif Binboga / Bahadir Kartal / Halil Alis
Published Online: 2019-07-18 | DOI: https://doi.org/10.1515/tjb-2018-0301

Abstract

Background

The aim of this study was to investigate the importance of fibrinopeptide-A and fibrinopeptide-B, which occur during the formation of D-dimer, the most commonly used laboratory parameter, in the early diagnosis of acute mesenteric ischemia (AMI).

Materials and methods

This experimental study was performed in 30 male pathogen-free Wistar albino rats. The experimental animals were divided into 3 equal groups: Control group (n = 10), Sham group (n = 10) and Ischemia group (n = 10). Blood samples were taken 0, 1, 3, and 6 h after the simulation of mesenteric ischemia.

Results

Fibrinopeptide-A and fibrinopeptide-B levels increased significantly in the first 6 h in the ischemic group, similar to the increase in D-dimer levels. The statistical change between 0, 1, 3 and 6 h was more significant for fibrinopeptide-A and fibrinopeptide-B.

Conclusion

Fibrinopeptide-A and fibrinopeptide-B may be markers that can be used for early diagnosis of mesenteric ischemia, early diagnosis is highly important for decreasing mortality and morbidity.

ÖZ

Amaç

Bu çalışmanın amacı akut mesenterik iskeminin erken tanısında en sık kullanılan laboratuvar parametresi olan D-dimerin oluşumu sürecinde ortaya çıkan Fibrinopetid-A ve Fibrinopeptid-B’ nin önemini araştırmaktır.

Gereç ve Yöntem

Bu deneysel çalışma 30 erkek-patojen içermeyen Wistar-albino sıçanda gerçekleştirildi. Deney hayvanları; Kontrol grubu (n = 10), Sham grubu (n = 10) ve İskemi grubu (n = 10) olmak üzere 3 eşit gruba ayrıldı. Kan örnekleri mezenterik iskemi uyarımından 0, 1, 3 ve 6 saat sonra alındı.

Bulgular

İskemi grubunda ilk 6 saatte Fibrinopeptid-A ve Fibrinopeptid-B düzeyleri D-dimer seviyesindeki artışa benzer şekilde anlamlı olarak arttı. 0., 1., 3., ve 6. saatler arasındaki istatistiksel değişim, daha anlamlı tespit edildi.

Sonuç

Erken tanı mortalite ve morbiditeyi azaltmada çok önemlidir, Fibrinopeptid-A ve Fibrinopeptid-B mezenterik iskemi erken tanısında kullanılabilecek belirteçler olabilir.

Keywords: Acute mesenteric ischemia; D-dimer; Early diagnosis; Fibrinopeptide A; Fibrinopeptide B

Anahtar kelimeler: Akut Mezenterik İskemi; D-Dimer; Erken Tanı; Fibrinopeptide A; Fibrinopeptide B

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About the article

Received: 2018-07-20

Accepted: 2018-12-11

Published Online: 2019-07-18

Published in Print: 2019-10-25


Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.


Citation Information: Turkish Journal of Biochemistry, Volume 44, Issue 5, Pages 654–660, ISSN (Online) 1303-829X, DOI: https://doi.org/10.1515/tjb-2018-0301.

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