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Turkish Journal of Biochemistry

Türk Biyokimya Dergisi


IMPACT FACTOR 2018: 0.329

CiteScore 2018: 0.28

SCImago Journal Rank (SJR) 2018: 0.138
Source Normalized Impact per Paper (SNIP) 2018: 0.169

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1303-829X
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Volume 43, Issue 3

Issues

Large unstained cells are correlated with inflammatory biomarkers in patients with invasive aspergillosis

Büyük boyanmamış hücreler invaziv aspergillozis hastalarında enflamatuvar biyobelirteçler ile koreledir

Isil CakirORCID iD: http://orcid.org/0000-0001-5728-4671 / Nuri Cakir / Mustafa Altay Atalay / Ayse Nedret Koc
Published Online: 2018-01-25 | DOI: https://doi.org/10.1515/tjb-2017-0042

Abstract

Objective:

The percentage of large unstained cells (%LUCs) reflects peroxidase-negative cells and activated lymphocytes. Unlike other infections, the value of %LUCs in the diagnosis of fungal infections is not clear. We aimed to evaluate %LUCs and its correlations with other inflammatory parameters of invasive aspergillosis (IA) patients.

Methods:

Twenty patients and 20 healthy participants were included. Full blood count parameters including %LUCs values were recorded. Platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), eosinophil to lymphocyte ratio (ELR) were calculated.

Results:

There was a significant difference between the study groups for %LUCs [2.40 (2.22–3.25); 1.43 (1.25–2.10), respectively; p<0.001]. Furthermore, %LUCs were statistically significantly correlated with PLR, NLR and MLR (p=0.020, 0.040, 0.040; respectively) but not correlated with ELR (p>0.05).

Conclusion:

The %LUCs values were significantly increased and correlated with markers of inflammation in patients. We suggest that the %LUCs is a useful predictor and may be an aid in the diagnosis and/or the management of IA and may help clinicians for follow up these patients in therapy process. Our study provides target pathways for further studies in the diagnosis of Aspergillus-infected patients using inflammatory parameters.

Özet

Amaç:

Büyük boyanmamış hücre yüzdesi (%LUCs), peroksidaz negatif hücreleri ve aktive lenfositleri ifade eder. Diğer enfeksiyonlardan farklı olarak, fungal enfeksiyonların teşhisinde %LUCs değeri açık değildir. İnvaziv aspergilloz (IA) hastalarında %LUCs ve bunun diğer enflamatuvar parametrelerle korelasyonunu değerlendirmeyi amaçladık.

Metodlar:

Yirmi hasta ve yirmi sağlıklı katılımcı dahil edildi. %LUCs değerlerini de içeren tam kan sayımı parametreleri kaydedildi. Platelet/lenfosit oranı (PLR), nötrofil/lenfosit oranı (NLR), monosit/lenfosit oranı (MLR), eozinofil/lenfosit oranı (ELR) hesaplandı.

Bulgular:

Çalışma grupları arasında %LUCs anlamlı farklı idi [2.40 (2.22–3.25); 1.43 (1.25–2.10), sırasıyla; p<0.001]. Ayrıca, %LUCs değeri PLR, NLR ve MLR ile anlamlı korele (sırasıyla p=0.020, 0.040, 0.040) fakat ELR ile korele değil idi (p>0.05).

Sonuç:

Hastalarda %LUCs değerleri anlamlı yüksek ve enflamasyon belirteçleri ile korele idi. %LUCs değerinin faydalı bir belirteç olduğunu, IA tanısı ve/kontrolünde destek olabileceğini ve bu hastaların tedavi süreçlerinde takipleri için klinisyenlere yardım edebileceğini önermekteyiz. Çalışmamız, enflamasyon parametrelerini kullanarak Aspergillus- enfekte hastaların teşhisinde, ileri çalışmalar için hedef yolaklar sağlamaktadır.

Keywords: Invasive aspergillosis; Large unstained cells; Inflammation; Platelet to lymphocyte ratio; Neutrophil to lymphocyte ratio; Monocyte to lymphocyte ratio; Eosinophil to lymphocyte ratio

Anahtar Kelimeler: İnvaziv aspergilloz; Büyük boyanmamış hücreler; Enflamasyon; Platelet/lenfosit oranı; Nötrofil/lenfosit oranı; Monosit/lenfosit oranı; Eozinofil/lenfosit oranı

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About the article

Corresponding author: Dr. Isil Cakir, Department of Clinical Biochemistry, Training and Research Hospital, 38010 Kayseri, Turkey, Phone: +903523368884-1219, 1239


Received: 2017-02-07

Accepted: 2017-10-24

Published Online: 2018-01-25


Conflict of interest statement: No conflict of interest was declared by the authors.


Citation Information: Turkish Journal of Biochemistry, Volume 43, Issue 3, Pages 306–311, ISSN (Online) 1303-829X, DOI: https://doi.org/10.1515/tjb-2017-0042.

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