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Translational Neuroscience

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Spherical harmonic analysis of cortical complexity in autism and dyslexia

Emily Williams / Ayman El-Baz / Matthew Nitzken / Andrew Switala / Manuel Casanova
Published Online: 2012-03-14 | DOI: https://doi.org/10.2478/s13380-012-0008-y

Abstract

Alterations in gyral form and complexity have been consistently noted in both autism and dyslexia. In this present study, we apply spherical harmonics, an established technique which we have exapted to estimate surface complexity of the brain, in order to identify abnormalities in gyrification between autistics, dyslexics, and controls. On the order of absolute surface complexity, autism exhibits the most extreme phenotype, controls occupy the intermediate ranges, and dyslexics exhibit lesser surface complexity. Here, we synthesize our findings which demarcate these three groups and review how factors controlling neocortical proliferation and neuronal migration may lead to these distinctive phenotypes.

Keywords: Cerebral cortex; Gyral window; Gyrification index; Minicolumn; Neurogenesis

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About the article

Published Online: 2012-03-14

Published in Print: 2012-03-01


Citation Information: Translational Neuroscience, ISSN (Online) 2081-6936, ISSN (Print) 2081-3856, DOI: https://doi.org/10.2478/s13380-012-0008-y.

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© 2012 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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