Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Translational Neuroscience

1 Issue per year

IMPACT FACTOR 2016: 0.922
5-year IMPACT FACTOR: 1.030

CiteScore 2016: 1.13

SCImago Journal Rank (SJR) 2015: 0.704
Source Normalized Impact per Paper (SNIP) 2015: 0.286

Open Access
See all formats and pricing
In This Section

Malignant transformation of grade II ganglioglioma to glioblastoma: A case report

Hrvoje Čupić
  • University Hospital Sestre milosrdnice, Zagreb, Croatia
  • Email:
/ Tomislav Sajko
  • University Hospital Sestre milosrdnice, Zagreb, Croatia
  • Email:
/ Nikolina Sesar
  • University Hospital Sestre milosrdnice, Zagreb, Croatia
  • Email:
/ Mihovil Ivica
  • University Hospital Sestre milosrdnice, Zagreb, Croatia
  • Email:
/ Leo Pažanin
  • University Hospital Sestre milosrdnice, Zagreb, Croatia
  • Email:
Published Online: 2012-06-01 | DOI: https://doi.org/10.2478/s13380-012-0017-x


Gangliogliomas are well differentiated and slowly growing neuroepithelial tumors composed of neoplastic ganglion cells and neoplastic glial cells corresponding mostly to the World Health Organization grade I tumors. However, some of these tumors disclose histologically more malignant glial component and correspond to grade II or grade III tumors. We report a case of left temporal lobe tumor in a 42-year-old woman fulfilling the diagnostic criteria for atypical (grade II) ganglioglioma with high Ki-67 proliferation index and p53 immunoreactive tumor cells. In spite of gross total removal of the tumor, it recurred eight months after surgery. Histopathological examination of the recurrent tumor revealed that it had undergone malignant transformation into a glioblastoma. This case indicates that gangliogliomas with high Ki-67 proliferating index and p53 immunoreactivity should be carefully monitored for recurrence and malignant progression regardless of their morphological grading and seemingly total surgical removal.

Keywords: Ganglioglioma; Malignant transformation; Glioblastoma

  • [1] Kleihues P., Cavenee W.K., Pathology and genetics of tumours of the nervous system, IARC Press, Lyon, 2007

  • [2] Majores M., von Leche M., Fassunke J., Schramm J., Becker J.A., Simon M., Tumor recurrence and malignant progression of gangliogliomas, Cancer, 2008, 113, 3355–3363 http://dx.doi.org/10.1002/cncr.23965 [Crossref]

  • [3] Luyken C., Blumcke I., Fimmers R., Urbach H., Wiestler O.D., Schramm J., Supratentorial gangliogliomas: histopathological grading and tumor recurrence in 184 patients with median follow-up of 8 years, Cancer, 2004, 101, 146–155 http://dx.doi.org/10.1002/cncr.20332

  • [4] Castillo M., Gangliogliomas: ubiquitous or not?, Am. J. Neuroradiol., 1998, 19, 807–809

  • [5] Wolf H.K., Muller M.B., Spanle M., Zenther J., Scheramm J., Weistler O.D., Ganglioglioma: a detailed histopathological and immunohistochemical study, Acta Neuropathol. (Berl.), 1994, 88, 166–173 http://dx.doi.org/10.1007/BF00294510 [Crossref]

  • [6] Blumcke I., Weistler O.D., Gangliogliomas: an intriguing tumor entity associated with focal epilepsies, J. Neuropathol. Exp. Neurol., 2002, 61, 575–584

  • [7] Rumana C.S., Valadka A.B., Radiation therapy and malignant degeenration of benign supratentorial gangliogliomas, Neurosurgery, 1998, 42, 1038–1043 http://dx.doi.org/10.1097/00006123-199805000-00049 [Crossref]

  • [8] Hayashi Y., Iwato M., Hasegawa M., Tachibana O., von Deimling A., Yamashita J., Malignant transformation of a gangliocytoma/ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis. Case report., J. Neurosurg., 2001, 95, 138–142 http://dx.doi.org/10.3171/jns.2001.95.1.0138 [Crossref]

  • [9] Jay A., Squire J., Becker L.E., Malignant transformation in a ganglioglioma with anaplastic neuronal and astrocytic components. Report of a case with flow cytometric and cytogenetic analysis., Cancer, 1994, 73, 2862–2868 http://dx.doi.org/10.1002/1097-0142(19940601)73:11<2862::AID-CNCR2820731133>3.0.CO;2-5 [Crossref]

  • [10] Kalyan-Raman U.P., Olivero W.C., Ganglioglioma: a correlative clinicopathological and radiological study often surgically treated cases with follow-up, Neurosurgery, 1987, 20, 428–433 http://dx.doi.org/10.1227/00006123-198703000-00012 [Crossref]

  • [11] Kim N.R., Wang K.-C., Bang J.-S., Choe G., Park Y., Kim S.-K., et al., Glioblastomaotus transformation of ganglioglioma: case report with reference to molecular genetic and flow cytometric analysis, Pathol. Int., 2003, 53, 874–882 http://dx.doi.org/10.1046/j.1440-1827.2003.01574.x [Crossref]

  • [12] Pandita A., Balasubramaniam A., Perrin R., Shannon P., Guha A., Malignant and benign ganglioglioma: a pathological and molecular study, Neuro Oncol., 2007, 9, 124–134 http://dx.doi.org/10.1215/15228517-2006-029 [Crossref]

  • [13] Hirose T., Kannuki S., Nishida K., Matsumoto K., Sano T. and Hizawa K., Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells, Acta Neuropathol. (Berl.), 1992, 83, 365–370 http://dx.doi.org/10.1007/BF00713527 [Crossref]

About the article

Published Online: 2012-06-01

Published in Print: 2012-06-01

Citation Information: Translational Neuroscience, ISSN (Online) 2081-6936, ISSN (Print) 2081-3856, DOI: https://doi.org/10.2478/s13380-012-0017-x. Export Citation

© 2012 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

Comments (0)

Please log in or register to comment.
Log in