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Translational Neuroscience

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Untangling the role of tau in Alzheimer’s disease: A unifying hypothesis

Neha Bhatia
  • Department of Biological Sciences, University of Massachusetts Lowell, 198 Riverside Street, Lowell, MA, 01854, USA
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/ Garth Hall
  • Department of Biological Sciences, University of Massachusetts Lowell, 198 Riverside Street, Lowell, MA, 01854, USA
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-06-09 | DOI: https://doi.org/10.2478/s13380-013-0114-5


Recent investigations into the etiology and pathogenesis of Alzheimer’s disease (AD) in the past few years have expanded to include previously unexplored and/or disconnected aspects of AD and related conditions at both the cellular and systemic levels of organization. These include how AD-associated abnormalities affect the cell cycle and neuronal differentiation state and how they recruit signal transduction, membrane trafficking and protein transcytosis mechanisms to produce a neurotoxic syndrome capable of spreading itself throughout the brain. The recent expansion of AD research into intercellular and new aspects of cellular degenerative mechanisms is causing a systemic re-evaluation of AD pathogenesis, including the roles played by well-studied elements, such as the generation of Aβ and tau protein aggregates. It is also changing our view of neurodegenerative diseases as a whole. Here we propose a conceptual framework to account for some of the emerging aspects of the role of tau in AD pathogenesis.

Keywords: Tauopathy; Secretion; Alzheimer’s disease pathogenesis; Tau lesion spread; Neurodegeneration; Tauopathy models; Tauopathy hypothesis

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About the article

Published Online: 2013-06-09

Published in Print: 2013-06-01

Citation Information: Translational Neuroscience, Volume 4, Issue 2, Pages 115–133, ISSN (Online) 2081-6936, ISSN (Print) 2081-3856, DOI: https://doi.org/10.2478/s13380-013-0114-5.

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