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Translational Neuroscience

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Congenital brain anomalies and chromosomal aberrations from the Zagreb Collection of human brains

Božo Krušlin
  • Department of Pathology, University of Zagreb School of Medicine, Zagreb, Croatia
  • Department of Pathology, Clinical Hospital Center Sestre milosrdnice, Zagreb, Croatia
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/ Tihana Džombeta
  • Department of Pathology, University of Zagreb School of Medicine, Zagreb, Croatia
  • Department of Pathology, Clinical Hospital Center Sestre milosrdnice, Zagreb, Croatia
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/ Miran Bezjak / Goran Sedmak / Zdravko Petanjek / Goran Šimić / Miloš Judaš / Ivica Kostović
Published Online: 2014-09-17 | DOI: https://doi.org/10.2478/s13380-014-0231-9


The Zagreb Collection of developing and adult human brains consists of approximately 1,300 brains of fetuses, children and adults that were collected following routine autopsies in the period from 1974 to 2014. The collection comprises brains of different normal developmental stages that may serve for investigation of normal human brain development. Previous studies on this material have led to several important contributions on human cortical development, such as the discovery of the transient fetal subplate zone. The Zagreb Collection, however, also contains approximately 100 brains with different anomalies including chromosomal aberrations such as Down syndrome. We have analyzed all the available material from the Zagreb Collection and identified 44 brains of fetuses and children with Down syndrome, 10 with Patau syndrome, 6 with Edwards syndrome as well as 7 holoprosencephalic, 7 hydrocephalic and 4 microcephalic brains. The largest part of the Collection is available for further research using modern genetic, immunocytochemical and imaging methods, especially magnetic resonance imaging. Furthermore, the histological slides from the Zagreb Collection are currently being digitally scanned and made available as virtual slides to general scientific audience. The Zagreb Collection represents unique and versatile resource for the future study of normal and abnormal human brain development.

Keywords: Brain; Collection; Anomalies; Down syndrome; Patau syndrome; Edwards syndrome

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About the article

Published Online: 2014-09-17

Published in Print: 2014-12-01

Citation Information: Translational Neuroscience, Volume 5, Issue 4, Pages 293–301, ISSN (Online) 2081-6936, DOI: https://doi.org/10.2478/s13380-014-0231-9.

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© 2014 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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