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Translational Neuroscience

Editor-in-Chief: Šimic, Goran

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IMPACT FACTOR 2015: 1.012

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A novel head-neck cooling device for concussion injury in contact sports

Huan Wang
  • Department of Neurosurgery, Carle Foundation Hospital, University of Illinois College of Medicine at Urbana-Champaign, Urbana, USA
  • Thermal Neuroscience Laboratory, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, USA
/ Bonnie Wang
  • Department of Internal Medicine, Carle Foundation Hospital, University of Illinois College of Medicine at Urbana-Champaign, Urbana, USA
/ Kevin Jackson
  • Thermal Neuroscience Laboratory, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, USA
/ Claire M. Miller
  • Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, USA
/ Linda Hasadsri
  • Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
/ Daniel Llano
  • Department of Molecular and Integrative Physiology, University of Illinois College of Medicine at Urbana-Champaign, Carle Foundation Hospital, Urbana, USA
  • The Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, USA
/ Rachael Rubin
  • The Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, USA
/ Jarred Zimmerman
  • Department of Sports Medicine, Carle Foundation Hospital, Urbana, USA
/ Curtis Johnson
  • The Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, USA
  • Department of Mechanical Science and Engineering, University of Illinois at Urbana- Champaign, Urbana, USA
/ Brad Sutton
  • The Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, USA
  • Department of Neurosurgery, Carle Foundation Hospital, University of Illinois College of Medicine at Urbana-Champaign, Urbana, USA
  • Department of Electrical and Computer Engineering, University of Illinois at Urbana- Champaign, Urbana, USA
Published Online: 2015-01-14 | DOI: https://doi.org/10.1515/tnsci-2015-0004

Abstract

Emerging research on the long-term impact of concussions on athletes has allowed public recognition of the potentially devastating effects of these and other mild head injuries. Mild traumatic brain injury (mTBI) is a multifaceted disease for which management remains a clinical challenge. Recent pre-clinical and clinical data strongly suggest a destructive synergism between brain temperature elevation and mTBI; conversely, brain hypothermia, with its broader, pleiotropic effects, represents the most potent neuro-protectant in laboratory studies to date. Although well-established in selected clinical conditions, a systemic approach to accomplish regional hypothermia has failed to yield an effective treatment strategy in traumatic brain injury (TBI). Furthermore, although systemic hypothermia remains a potentially valid treatment strategy for moderate to severe TBIs, it is neither practical nor safe for mTBIs. Therefore, selective head-neck cooling may represent an ideal strategy to provide therapeutic benefits to the brain. Optimizing brain temperature management using a National Aeronautics and Space Administration (NASA) spacesuit spinoff head-neck cooling technology before and/or after mTBI in contact sports may represent a sensible, practical, and effective method to potentially enhance recover and minimize post-injury deficits. In this paper, we discuss and summarize the anatomical, physiological, preclinical, and clinical data concerning NASA spinoff head-neck cooling technology as a potential treatment for mTBIs, particularly in the context of contact sports.

Keywords: Head-neck cooling; Mild traumatic brain injury; Brain hypothermia; Brain temperature; Sports

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About the article

Received: 2014-11-09

Accepted: 2014-11-29

Published Online: 2015-01-14


Citation Information: Translational Neuroscience, ISSN (Online) 2081-6936, DOI: https://doi.org/10.1515/tnsci-2015-0004. Export Citation

©2015 Huan Wang et al. . This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

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