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Zeitschrift für Kristallographie - Crystalline Materials

Editor-in-Chief: Pöttgen, Rainer

Ed. by Antipov, Evgeny / Boldyreva, Elena V. / Friese, Karen / Huppertz, Hubert / Jahn, Sandro / Tiekink, E. R. T.


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2196-7105
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Volume 211, Issue 9

Issues

Molecular and crystal structures of two terminally-blocked Ac5c homo-oligopeptides

A. Santini / B. Di Blasio / S. Galdiero / R. Iacovino / C. Pedone / E. Benedetti / M. Crisma / C. Toniolo
Published Online: 2010-07-28 | DOI: https://doi.org/10.1524/zkri.1996.211.9.616

Abstract

The molecular and crystal structures of the terminally blocked homo-tri- and homo-pentapeptides from 1-amino-1-cyclopentane-carboxylic acid, Z-(Ac5c)3-OtBu (1) and Z-(Ac5c)5-OtBu (2), were determined by X-ray diffraction. The two compounds exhibit the following parameters: (1) orthorhombic, P212121, a = 11.539(7) Å, b = 16.185(2) Å, c = 30.925(4) Å and Z = 8; (2) triclinic, P[unk], a = 10.835(5) Å, b = 11.631(9) Å, c = 18.212(5) Å, α = 92.20(7)°, β = 94.79(10)°, γ = 107.6(3)° and Z = 2. The crystal structures were solved by direct methods. The least-squares refinements led to R values of 0.080 and 0.060 for 4061 and 4018 reflections with I ≥ 2σ(I) (according to the SHELXL-93 computer program weighting scheme) for (1) and I ≥ 3σ(I) (Structure Determination Programs, SDP crystallographic package weighting scheme) for (2), respectively. The two independent molecules, A and B, in the asymmetric unit of the tripeptide (1) are folded into a type-I/III and a type-I′/β-bend conformation, respectively, each stabilized by an intramolecular C=O…H–N H-bond. The pentapeptide molecules adopt a 310-helical structure, stabilized by three consecutive, intramolecularly H-bonded type-III (III′) β-bend conformations.

About the article

Published Online: 2010-07-28

Published in Print: 1996-09-01


Citation Information: Zeitschrift für Kristallographie - Crystalline Materials, Volume 211, Issue 9, Pages 616–621, ISSN (Online) 2196-7105, ISSN (Print) 2194-4946, DOI: https://doi.org/10.1524/zkri.1996.211.9.616.

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[2]
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[3]
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