Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Zeitschrift für Kristallographie - Crystalline Materials

Editor-in-Chief: Pöttgen, Rainer

Ed. by Antipov, Evgeny / Bismayer, Ulrich / Boldyreva, Elena V. / Friese, Karen / Huppertz, Hubert / Tiekink, E. R. T.

12 Issues per year

IMPACT FACTOR 2017: 1.263
5-year IMPACT FACTOR: 2.057

CiteScore 2017: 2.65

See all formats and pricing
More options …
Volume 227, Issue 11


The multiple effects of amino acids on the early stages of calcium carbonate crystallization

Andreas Picker / Matthias Kellermeier / Jong Seto / Denis Gebauer / Helmut Cölfen
Published Online: 2012-10-15 | DOI: https://doi.org/10.1524/zkri.2012.1569


Proteins have found their way into many of Nature’s structures due to their structural stability, diversity in function and composition, and ability to be regulated as well as be regulators themselves. In this study, we investigate the constitutive amino acids that make up some of these proteins which are involved in CaCO3 mineralization – either in nucleation, crystal growth, or inhibition processes. By assaying all 20 amino acids with vapor diffusion and in situ potentiometric titration, we have found specific amino acids having multiple effects on the early stages of CaCO3 crystallization. These same amino acids have been independently implicated as constituents in liquid-like precursors that form mineralized tissues, processes believed to be key effects of biomineralization proteins in several biological model systems.

This article offers supplementary material which is provided at the end of the article.

Keywords: Calcium carbonate; Amino acids; Nucleation; Crystal growth; Prenucleation clusters

About the article

* Correspondence address: University of Konstanz, Physical Chemistry, Universitätsstrasse 10, Box 714, 78457 Konstanz, Deutschland,

Published Online: 2012-10-15

Published in Print: 2012-11-01

Citation Information: Zeitschrift für Kristallographie - Crystalline Materials, Volume 227, Issue 11, Pages 744–757, ISSN (Print) 2194-4946, DOI: https://doi.org/10.1524/zkri.2012.1569.

Export Citation

Supplementary Article Materials

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Ashit Rao, Markus Drechsler, Stefan Schiller, Martin Scheffner, Denis Gebauer, and Helmut Cölfen
Advanced Functional Materials, 2018, Page 1802063
Lara Štajner, Jasminka Kontrec, Branka Njegić Džakula, Nadica Maltar-Strmečki, Milivoj Plodinec, Daniel M. Lyons, and Damir Kralj
Journal of Crystal Growth, 2018, Volume 486, Page 71
R. Innocenti Malini, A. R. Finney, S. A. Hall, C. L. Freeman, and J. H. Harding
Crystal Growth & Design, 2017
Gaurav Jain, Martin Pendola, Yu-Chieh Huang, Jose Juan Colas, Denis Gebauer, Steven Johnson, and John Spencer Evans
Biochemistry, 2017, Volume 56, Number 28, Page 3607
Chaeyeon Son, Sun Young Kim, So Yeong Bahn, Hyung Joon Cha, and Yoo Seong Choi
RSC Adv., 2017, Volume 7, Number 25, Page 15302
Eva Weber, Ingrid M. Weiss, Helmut Cölfen, and Matthias Kellermeier
CrystEngComm, 2016, Volume 18, Number 43, Page 8439
Josue A. Lopez-Berganza and Rosa M. Espinosa-Marzal
Crystal Growth & Design, 2016, Volume 16, Number 11, Page 6186
Carlos Rodríguez-Navarro, Encarnación Ruiz-Agudo, Joe Harris, and Stephan E. Wolf
Journal of Structural Biology, 2016, Volume 196, Number 2, Page 260
David C. Green, Johannes Ihli, Yi-Yeoun Kim, Samantha Y. Chong, Phillip A. Lee, Christopher J. Empson, and Fiona C. Meldrum
Crystal Growth & Design, 2016, Volume 16, Number 9, Page 5174
Chaeyeon Son, Wooho Song, Dong Soo Hwang, Yong-Ki Hong, Jin Joo, and Yoo Seong Choi
Korean Journal of Chemical Engineering, 2016, Volume 33, Number 8, Page 2406
Eric P. Chang, Teresa Roncal-Herrero, Tamara Morgan, Katherine E. Dunn, Ashit Rao, Jennie A. M. R. Kunitake, Susan Lui, Matthew Bilton, Lara A. Estroff, Roland Kröger, Steven Johnson, Helmut Cölfen, and John Spencer Evans
Biochemistry, 2016, Volume 55, Number 16, Page 2401
Ashit Rao, Patricio Vásquez-Quitral, María S. Fernández, John K. Berg, Marianela Sánchez, Markus Drechsler, Andrónico Neira-Carrillo, José L. Arias, Denis Gebauer, and Helmut Cölfen
Crystal Growth & Design, 2016, Volume 16, Number 3, Page 1349
Wooho Song, So Yeong Bahn, Hyung Joon Cha, Seung Pil Pack, and Yoo Seong Choi
Biotechnology Letters, 2016, Volume 38, Number 5, Page 809
Stefan L. P. Wolf, Kathrin Jähme, and Denis Gebauer
CrystEngComm, 2015, Volume 17, Number 36, Page 6857
Jens Kahlen, Christine Peter, and Davide Donadio
CrystEngComm, 2015, Volume 17, Number 36, Page 6863
Yougang Guo, Jinle Lan, Caijin Zhang, Man Cao, Qing Cai, and Xiaoping Yang
Applied Surface Science, 2015, Volume 349, Page 538
Ashit Rao, María S. Fernández, Helmut Cölfen, and José L. Arias
Crystal Growth & Design, 2015, Volume 15, Number 5, Page 2052
Anastasia Brif, Leonid Bloch, and Boaz Pokroy
CrystEngComm, 2014, Volume 16, Number 16, Page 3268
Fitriana Nindiyasari, Lurdes Fernández-Díaz, Erika Griesshaber, José Manuel Astilleros, Nuria Sánchez-Pastor, and Wolfgang W. Schmahl
Crystal Growth & Design, 2014, Volume 14, Number 4, Page 1531
Anastasia Brif, Guy Ankonina, Christina Drathen, and Boaz Pokroy
Advanced Materials, 2014, Volume 26, Number 3, Page 477
Josef Eiblmeier, Ulrich Schürmann, Lorenz Kienle, Denis Gebauer, Werner Kunz, and Matthias Kellermeier
Nanoscale, 2014, Volume 6, Number 24, Page 14939
Iva Perovic, Andreas Verch, Eric P. Chang, Ashit Rao, Helmut Cölfen, Roland Kröger, and John Spencer Evans
Biochemistry, 2014, Volume 53, Number 46, Page 7259
Jens Rieger, Matthias Kellermeier, and Luc Nicoleau
Angewandte Chemie International Edition, 2014, Page n/a
Jens Rieger, Matthias Kellermeier, and Luc Nicoleau
Angewandte Chemie, 2014, Volume 126, Number 46, Page 12586
Eva Weber, Leonid Bloch, Christina Guth, Andy N. Fitch, Ingrid M. Weiss, and Boaz Pokroy
Chemistry of Materials, 2014, Volume 26, Number 17, Page 4925
Ashit Rao, Jong Seto, John K. Berg, Stefan G. Kreft, Martin Scheffner, and Helmut Cölfen
Journal of Structural Biology, 2013, Volume 183, Number 2, Page 205

Comments (0)

Please log in or register to comment.
Log in