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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences

12 Issues per year

IMPACT FACTOR 2017: 0.757

CiteScore 2017: 0.68

SCImago Journal Rank (SJR) 2017: 0.277
Source Normalized Impact per Paper (SNIP) 2017: 0.394

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Volume 20, Issue 6


Über die Wirkung von Heparin, Heparinoiden und Carrageenin auf die Komponenten des Meerschweinchen-Komplements in vitro

K. Lauenstein / H. G. Siedentopf / H. Fischer
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znb-1965-0616

The mode of action of six inhibitors of the complement system of guinea pig serum was analysed by use of the method described in the preceding paper.

Carrageenin is the most powerful inhibitor followed by polyvinylalcoholsulfate, polyethenesulfate, heparinoid “Bayer”, dextransulfate, and heparin. All six substances are directed against C′ 1 and C′ 2. Heparin and polyethenesulfate also inhibit C′ 3b,β, while an effect of heparinoid “Bayer”, dextransulfate, and polyvinylalcoholsulfate upon C′ 3b,β could not definitely be demonstrated. It is not clear whether these latter substances act upon C′ 3b,β, C′ 3c,d, or upon both components.

All substances tested exert the strongest inhibitory effect upon C′ 1 which thus becomes the limiting component in guinea pig complement.

About the article

Received: 1965-01-23

Published Online: 2014-06-02

Published in Print: 1965-06-01

Citation Information: Zeitschrift für Naturforschung B, Volume 20, Issue 6, Pages 575–581, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-1965-0616.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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