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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences

12 Issues per year

IMPACT FACTOR 2017: 0.757

CiteScore 2017: 0.68

SCImago Journal Rank (SJR) 2017: 0.277
Source Normalized Impact per Paper (SNIP) 2017: 0.394

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Volume 22, Issue 5


Zur Biosynthese des formgebenden Elements der Bakterienzellwand

I. Abbau des Mureins als erster Schritt beim Wachstum des Sacculus

W. Leutgeb / U. Schwarz
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znb-1967-0519

Two stages in murein-biosynthesis — first, the partial degradation of the preexistent murein and second, the neosynthesis immediately following it under normal conditions — can be separated by DAP *-starvation of the DAP-dependent mutant of E. coli W 173-25. In order to investigate the function of mureinhydrolases in murein-biosynthesis, the degradation of murein in growing cells has been studied using a new method. Evidence is presented which indicates that a muramylendopeptidase plays a major role in the process. The activity of this enzyme is revealed by a conversion of the cells into spheroplasts upon DAP-starvation.

A hypothesis concerning the insertion of new murein moieties due to transpeptidation by this enzyme is discussed.

About the article

Received: 1966-11-03

Published Online: 2014-06-02

Published in Print: 1967-05-01

Citation Information: Zeitschrift für Naturforschung B, Volume 22, Issue 5, Pages 545–549, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-1967-0519.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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