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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Covalent Binding of Polypeptides to Sulfonium Resins

  • Angelo Fontana , Francesco M. Veronese and Enrico Boccu’

Basic dimethyl-arylmethylene-sulfonium resins (L. C. DORMAN and J. LOVE, J. org. Chemistry 34, 158 [1969] have been used as reactive supports for the covalent binding of N-protected as well as N-unprotected peptides through a benzyl ester linkage. Example are given of effective coupling of peptides of rather long sequence, the quantity of peptide linked being up to 0.5 μmole per mg of resin. The method could find practical use in the solid state degradation of polypeptides.

Received: 1971-1-9
Published Online: 2014-6-2
Published in Print: 1971-4-1

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This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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