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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences

12 Issues per year

IMPACT FACTOR 2017: 0.757

CiteScore 2017: 0.68

SCImago Journal Rank (SJR) 2017: 0.277
Source Normalized Impact per Paper (SNIP) 2017: 0.394

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Volume 40, Issue 11


Reaction of Malononitrile and Ethyl Cyanoacetate: a Novel Synthesis of Polyfunctional Pyridine Derivatives

R. M. Mohareb / S. M. Fahmy
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znb-1985-1120

Malononitrile reacts with ethyl cyanoacetate to give a polyfunctional substituted pyridine derivative 5. The latter compound reacts with aniline, hydrazines and aromatic aldehydes to give condensated products. The active methylene of 5 couples with benzenediazonium chloride to give the phenylhydrazone derivative which cyclises readily to give a pyrido[2,3-d]pyridazine deriva­tive. 5 reacts with trichloroacetonitrile, and carbon disulphide to give fused heterocyclic deriva­tives.

Keywords: Malononitrile; Ethyl Cyanoacetate; Pyridine Derivatives

About the article

Received: 1985-04-30

Published Online: 2014-06-02

Published in Print: 1985-11-01

Citation Information: Zeitschrift für Naturforschung B, Volume 40, Issue 11, Pages 1537–1540, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-1985-1120.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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