Abstract
The ratios of reduced and oxidized nicotinamide nucleotides (NADH/NAD+ and NADPH/ NADP+) were indirectly determined at various stages of cataractogenesis by estimating the concentrations of metabolites (lactate, pyruvate and malate) of the lens. The ratios of NADH/NAD+ and NADPH/NADP+ decreased significantly from immature to mature (P<.001, P<.05). to hypermature (P<.001, P<.05), to Morgagnian (Pc.001. Pc.001) and diabetic types (Pc.001, P < .001) of cataractous lenses respectively. Ratios of nicotinamide nucleotides in diabetic lenses were lower in comparison to those of other types studied. As the opacity progressed, the ratios decreased with increase in blood glucose levels.
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