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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences


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1865-7117
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Volume 61, Issue 9

Issues

Dimethyl Sulfoxide Containing Platinum(II) and Palladium(II) Chelate Complexes of Glyoxylic and Pyruvic Acid Thiosemicarbazones. A New Class of Cytotoxic Metal Complexes

Nicolay I. Dodoff
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  • Institute of Molecular Biology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 21, 1113 Sofia, Bulgaria
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/ Dimitra Kovala-Demertzi
  • Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 451 10 Ioannina, Greece
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Maria Kubiak / Janina Kuduk-Jaworska / Andrzej Kochel / Galina A. Gorneva
  • Institute of Molecular Biology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 21, 1113 Sofia, Bulgaria
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  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znb-2006-0909

Abstract

The complexes [Pt(DMSO)(GT)]·DMSO (1), [Pt(DMSO)(PT)]· 1/2 DMSO (2) and [Pd(DMSO)- (PT)] (3), where DMSO = dimethyl sulfoxide, H2GT = glyoxylic acid thiosemicarbazone and H2PT = pyruvic acid thiosemicarbazone, have been synthesized and characterized by elemental analysis, molar electric conductivity, IR, electronic and NMR (1H and 13C) spectra. The single crystal X-ray diffraction analysis has revealed for 1 (orthorhombic, Pnma, a = 12.941(3), b = 7.108(2), c = 15.148(3) Å , Z = 4) that the doubly deprotonated thiosemicarbazone molecule is coordinated to Pt(II) via the carboxylato O, azomethine N and thiolato S atoms forming two condensed fivemembered chelate rings. The fourth coordination site of Pt(II) is occupied by the S atom of DMSO. All the atoms of the complex molecule are coplanar except the methyl groups. The O atom of DMSO is in cis-position towards the thiolato-S atom (point group Cs). A system of hydrogen bonds of the type N-H· · ·O links the complex molecules between them and with the lattice DMSO molecules. Similar structures have been deduced for the remaining two complexes on the basis of spectroscopic data. The three complexes and the ligand H2GT exhibit cytotoxic activity against F4N leukemia cells, whereas the ligand H2PT is inactive.

Keywords: Palladium(II) and Platinum(II) Thiosemicarbazonato Complexes; Crystal Structure; Cytotoxic Activity

About the article

Received: 2006-02-14

Published Online: 2014-06-02

Published in Print: 2006-09-01


Citation Information: Zeitschrift für Naturforschung B, Volume 61, Issue 9, Pages 1110–1122, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-2006-0909.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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