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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences

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IMPACT FACTOR 2016: 0.631

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1865-7117
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Volume 63, Issue 5

Issues

Heterocycles [h]-Fused onto 4-Oxoquinoline-3-carboxylic Acid, V [1]. Synthesis and Antibacterial Activity of Some New 2,3-Disubstituted 7-Oxo-7,10-dihydropyrido[2,3-f]quinoxaline-8-carboxylic Acids and Esters

Esra’a S. Abu-Sheaib / Jalal A. Zahra / Mustafa M. El-Abadelah / Wolfgang Voelter
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  • Interfakultäres Institut für Biochemie, Universität Tübingen, Hoppe-Seyler Straße 4, D-72076 Tübingen, Germany
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znb-2008-0513

Cyclocondensation reaction of ethyl 7,8-diamino-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline- 3-carboxylate (2) or the -3-carboxylic acid 3 with sym-1,2- diketones produced the corresponding ethyl 2,3-disubstituted pyrido[2,3- f ]quinoxaline-8-carboxylates (4a - h) or the -8-carboxylic acids 5a - h, respectively. The structures for these new heterocycles are supported by analytical and spectral (IR, MS, NMR) data. Compounds 5a - c, g, h exhibit moderate activity against an assortment of bacterial species.

Keywords : 7,8-Diamino-4-oxoquinoline-3-carboxylic Acid and Ester; sym-1,2-Diketones; Cyclocondensation; 7-Oxopyrido[2,3- f ]quinoxalines; Antibacterial Activity

About the article

Received: 2007-11-21

Published Online: 2014-06-02

Published in Print: 2008-05-01


Citation Information: Zeitschrift für Naturforschung B, Volume 63, Issue 5, Pages 555–563, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-2008-0513.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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