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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences


IMPACT FACTOR 2017: 0.757

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1865-7117
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Volume 65, Issue 10

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Synthesis and Characterization of New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell Lines

Wilfredo Hernández
  • Corresponding author
  • Facultad de Ingeniería Industrial, Universidad de Lima, Av. Javier Prado Este Cuadra 46, Urbanización Monterrico, Lima 33, Peru
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/ Juan Paz
  • Facultad de Ingeniería Industrial, Universidad de Lima, Av. Javier Prado Este Cuadra 46, Urbanización Monterrico, Lima 33, Peru
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/ Fernando Carrasco
  • Facultad de Ciencias, Universidad Nacional de Ingeniería, Av. Tupac Amaru 210, Rimac-Lima, Peru
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/ Abraham Vaisberg
  • Laboratorio de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, Urb. Ingeniería-San Martin de Porras, Lima 31, Peru
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/ Jorge Manzur
  • Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, CEDENNA, 8370448 Santiago, Chile
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/ Evgenia Spodine
  • Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, CEDENNA, Olivos 1007, Casilla 233, Independencia, 8330492 Santiago, Chile
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/ Lothar Hennig
  • Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany
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/ Joachim Sieler
  • Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany
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/ Lothar Beyer
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znb-2010-1015

With the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC1, (1), 4-phenyl-1- (5´-phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC2 (2), o-methoxy-benzaldehydethiosemicarbazone, HTSC3 (3), and o-cyano-benzaldehydethiosemicarbazone, HTSC4 (4), the corresponding palladium(II) complexes, Pd(TSC1)2 (5), Pd(TSC2)2 (6), Pd(TSC3)2 (7), and Pd(TSC4)2 (8) were synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structure of Pd(TSC3)2 (7) was determined by single-crystal X-ray diffraction. Complex 7 shows a squareplanar geometry, where two deprotonated ligands are coordinated to the PdII center through the nitrogen and sulfur atoms in a trans arrangement. In vitro antitumor studies against different human tumor cell lines have revealed that the palladium(II) complexes 5- 8 are more cytotoxic (IC50 values in the range of 0.21 - 3.79 μM) than their corresponding ligands (1 - 4) (> 60 μM). These results indicate that the antiproliferative activity is enhanced when thiosemicarbazone ligands are coordinated to the metal. Among the studied palladium(II) complexes, 8 exhibits high antitumor activity on K562 chronic myelogenous leukemia cells with a low value of the inhibitory concentration (IC50 = 0.21 μM).

Graphical Abstract

Synthesis and Characterization of New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell Lines

Synthesis and Characterization of New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell Lines

Keywords: Thiosemicarbazone; Palladium(II) Complexes; Crystal Structures; Antitumor/Cytotoxic Activity

About the article

Received: 2010-05-21

Published Online: 2014-06-02

Published in Print: 2010-10-01


Citation Information: Zeitschrift für Naturforschung B, Volume 65, Issue 10, Pages 1271–1278, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-2010-1015.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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Wilfredo Hernández, Abraham. J. Vaisberg, Mabel Tobar, Melisa Álvarez, Jorge Manzur, Yuri Echevarría, and Evgenia Spodine
New J. Chem., 2016, Volume 40, Number 2, Page 1853

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