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Publicly Available Published by De Gruyter June 2, 2014

Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Aromatic a-Bromoketones, Sodium Azide and Terminal Acetylenes via Cu/Cu(OTf)2-catalyzed Click Reaction under Microwave Irradiation

  • Azadeh Fazeli , Hossein A. Oskooie , Yahya S. Beheshtiha , Majid M. Heravi EMAIL logo , Firouz Matloubi Moghaddam and Behzad Koushki Foroushani

Reaction of aromatic a-bromoketones, sodium azide and aromatic or aliphatic terminal acetylenes in the presence of Cu/Cu(OTf)2 following the classical method (aqueous acetonitrile at room temperature) and under microwave irradiation (H2O at 85 °C) leads to 1,4-disubstituted 1,2,3-triazoles as the final products after simple filtration.

Graphical Abstract

 Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Aromatic a-Bromoketones, Sodium Azide and Terminal Acetylenes via Cu/Cu(OTf)2-catalyzed Click Reaction under Microwave Irradiation

Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Aromatic a-Bromoketones, Sodium Azide and Terminal Acetylenes via Cu/Cu(OTf)2-catalyzed Click Reaction under Microwave Irradiation

Received: 2013-2-11
Published Online: 2014-6-2
Published in Print: 2013-4-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

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