Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Zeitschrift für Naturforschung B

A Journal of Chemical Sciences

12 Issues per year


IMPACT FACTOR 2017: 0.757

CiteScore 2017: 0.68

SCImago Journal Rank (SJR) 2017: 0.277
Source Normalized Impact per Paper (SNIP) 2017: 0.394

Online
ISSN
1865-7117
See all formats and pricing
More options …
Volume 69, Issue 7

Issues

Synthesis of New TGX-221 Analogs

Chunjing Liu / Benyi Li
  • Department of Urology, The University of Kansas Medical Center, 3901 Rainbow Bouleward, Kansas City, KS66160, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Lester Mitscher
Published Online: 2014-06-02 | DOI: https://doi.org/10.5560/znb.2014-4081

TGX-221 is a potent phosphoinositide 3-kinase (PI3K)β inhibitor that has great therapeutic potential to treat prostate cancer. Chemical modification of TGX-221 at positions 2 and 9 was made. Five new TGX-221 analogs with different heterocyclic substituents of morpholine, 1-methylpiperazine, aniline, and thiazole-2-amine at positions 2 and 9 were synthesized. Parallel synthetic methods were employed in SN2 replacement reactions at positions 2 and 9 of TGX-221.

Graphical Abstract

Synthesis of New TGX-221 Analogs

Synthesis of New TGX-221 Analogs

Keywords: TGX-221; Heterocyclic Substituent; Parallel Synthesis; SN2 Reaction; Microwave Reaction

About the article

Received: 2014-03-31

Published Online: 2014-06-02

Published in Print: 2014-07-01


Citation Information: Zeitschrift für Naturforschung B, Volume 69, Issue 7, Pages 817–822, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.5560/znb.2014-4081.

Export Citation

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Chenchen He, Shaofeng Duan, Liang Dong, Yifen Wang, Qingting Hu, Chunjing Liu, Marcus L. Forrest, Jeffrey M. Holzbeierlein, Suxia Han, and Benyi Li
The Prostate, 2017, Volume 77, Number 11, Page 1187

Comments (0)

Please log in or register to comment.
Log in