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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences


IMPACT FACTOR 2018: 0.961

CiteScore 2018: 0.91

SCImago Journal Rank (SJR) 2018: 0.263
Source Normalized Impact per Paper (SNIP) 2018: 0.505

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1865-7117
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Volume 71, Issue 11

Issues

Environmentally benign synthesis of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using CeO2 nanoparticles as a reusable and robust catalyst

Javad Safaei-Ghomi
  • Corresponding author
  • Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, PO Box 87317-51167, Kashan, Iran (Islamic Republic of)
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/ Mehrnoosh Asgari-Kheirabadi
  • Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, PO Box 87317-51167, Kashan, Iran (Islamic Republic of)
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/ Hossein Shahbazi-Alavi
  • Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, PO Box 87317-51167, Kashan, Iran (Islamic Republic of)
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Published Online: 2016-08-17 | DOI: https://doi.org/10.1515/znb-2016-0119

Abstract

In this work, we report the synthesis and characterization of CeO2 nanoparticles as an efficient catalyst for the preparation of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates via one-pot four-component condensation reaction of dimethyl acetylenedicarboxylate, hydrazine hydrate, malononitrile, and aldehydes in aqueous medium. The use of a non-hazardous organic solvent, easy recovery of the catalyst, compatibility with various functional groups, and high yield of the products make the protocol attractive, greener, and economic.

Keywords: catalytic activity; CeO2 nanoparticles; multicomponent reactions; nanoparticles; one-pot; pyrano[2,3-c]pyrazole

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About the article

Received: 2016-05-11

Accepted: 2016-06-14

Published Online: 2016-08-17

Published in Print: 2016-11-01


Citation Information: Zeitschrift für Naturforschung B, Volume 71, Issue 11, Pages 1135–1140, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-2016-0119.

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