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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences


IMPACT FACTOR 2018: 0.961

CiteScore 2018: 0.91

SCImago Journal Rank (SJR) 2018: 0.263
Source Normalized Impact per Paper (SNIP) 2018: 0.505

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1865-7117
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Volume 72, Issue 10

Issues

Colletotrin: a sesquiterpene lactone from the endophytic fungus Colletotrichum gloeosporioides associated with Trichilia monadelpha

Pamela Nangmo Kemda
  • Department of Organic Chemistry, University of Yaounde I, Yaounde, Cameroon
  • Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Düsseldorf, Germany
  • Other articles by this author:
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/ Sergi H. Akone
  • Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Düsseldorf, Germany
  • Faculty of Science, Department of Chemistry, University of Douala, 24157 Douala, Cameroon
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Armelle Tsamo Tontsa
  • Department of Organic Chemistry, University of Yaounde I, Yaounde, Cameroon
  • Department of Chemistry, Tshwane University of Technology, Pretoria 0001, South Africa
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/ Liu Zhen
  • Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Düsseldorf, Germany
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/ Werner E.G. Müller
  • Institute of Physiological Chemistry and Pathobiochemistry, Johannes-Gutenberg University, 55128 Mainz, Germany
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/ Peter Proksch
  • Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Düsseldorf, Germany
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/ Augustin E. Nkengfack
Published Online: 2017-09-23 | DOI: https://doi.org/10.1515/znb-2017-0058

Abstract

A new sesquiterpene lactone, namely colletotrin (1), together with two known fungal metabolites (2, 3), was obtained from a rice culture of Colletotrichum gloeosporioides, an endophytic fungus isolated from the stem bark of Cameroonian medicinal plant Trichilia monadelpha (Meliaceae). The structure of the new compound was established on the basis of extensive NMR analysis (1H, 13C, heteronuclear single-quantum coherence and heteronuclear multiple-bond correlation) completed by high-resolution electrospray ionization mass spectroscopy results and by comparison of these data with those of related compounds described in the literature. Their cytotoxic and antibacterial activities against the mouse lymphoma L5178Y cell line and Mycobacterium tuberculosis, respectively, were also evaluated. This study is the first report on the isolation of fungal metabolites from endophytic fungi associated with T. monadelpha (Meliaceae).

This article offers supplementary material which is provided at the end of the article.

Keywords: anti-bacterial activities; Colletotrichum gloeosporioides; cytotoxicity; endophyte; sesquiterpene lactone

References

About the article

Received: 2017-04-06

Accepted: 2017-06-02

Published Online: 2017-09-23

Published in Print: 2017-09-26


Citation Information: Zeitschrift für Naturforschung B, Volume 72, Issue 10, Pages 697–703, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-2017-0058.

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Phytochemistry Letters, 2019, Volume 33, Page 90
[2]
Javier Moraga, Wesley Gomes, Cristina Pinedo, Jesús M. Cantoral, James R. Hanson, María Carbú, Carlos Garrido, Rosa Durán-Patrón, and Isidro G. Collado
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