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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences

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Volume 73, Issue 6


Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes

El Sayed Ramadan
  • Corresponding author
  • Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21524, A. R. Egypt
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/ Essam M. Sharshira
  • Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21524, A. R. Egypt
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/ Ramadan I. El Sokkary
  • Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21524, A. R. Egypt
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/ Noussa Morsy
  • Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21524, A. R. Egypt
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Published Online: 2018-05-18 | DOI: https://doi.org/10.1515/znb-2018-0009


A new series of chalcones, pyrazolinyl-pyrazoles, pyrazole-4-carbaldehyde oximes, pyrazole-4-carbonitriles, 5-pyrazolyl-1,2,4-triazolidine-3-thiones, and Knoevenagel condensation products was synthesized from 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes. Most reactions were carried out either without solvent or in the presence of water as a green solvent. The structure of synthesized compounds was characterized by spectral and elemental analysis. The synthesized compounds were tested in vitro for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans in comparison with imipenem (intravenous β-lactam antibiotic) and clotrimazole (antifungal medication) as reference drugs by using the agar diffusion technique. 3-Aryl-1-phenyl-1H-pyrazole-4-carbonitriles 8b, 8c, and 8d showed significant antifungal activity against the fungus C. albicans.

Keywords: antimicrobial activity; chalcones; green solvent; pyrazole-4-carbaldehyde; pyrazole-4-carbonitriles; solvent-free


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About the article

Received: 2018-01-07

Accepted: 2018-04-22

Published Online: 2018-05-18

Published in Print: 2018-06-27

Citation Information: Zeitschrift für Naturforschung B, Volume 73, Issue 6, Pages 389–397, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-2018-0009.

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