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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences

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IMPACT FACTOR 2017: 0.757

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Volume 73, Issue 9


Efficient synthesis of pyrido[2,3-d]pyrimidine-7-carboxylic acids catalyzed by a TiO2/SiO2 nanocomposite in aqueous media at room temperature

Sepehr Sadegh-Samiei
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  • Department of Chemistry, East Tehran Branch, Islamic Azad University, P.O. Box 18735-138, Tehran, Iran
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/ Shahrzad Abdolmohammadi
  • Young Researchers and Elite Club, East Tehran Branch, Islamic Azad University, P.O. Box 18735-138, Tehran, Iran
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Published Online: 2018-07-11 | DOI: https://doi.org/10.1515/znb-2018-0076


A novel and efficient synthesis of eight 5-aryl-1,3-dimethyl-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-7-carboxylic acids using a TiO2/SiO2 nanocomposite with a molar ratio of 1:1 as a recyclable heterogeneous catalyst is described. The desired products, five of which are new, are formed in short reaction times (2–3 h) with high to excellent yields (94%–98%) under very moderate reaction conditions (room temperature, aqueous media).

This article offers supplementary material which is provided at the end of the article.

Keywords: 1,3-dimethyl barbituric acid; 4-substituted phenylmethylidenepyruvic acids; aqueous media; pyrido[2,3-d]pyrimidine-7-carboxylic acids; recyclability of catalyst; TiO2/SiO2 nanocomposite


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About the article

Received: 2018-04-19

Accepted: 2018-06-14

Published Online: 2018-07-11

Published in Print: 2018-09-25

Citation Information: Zeitschrift für Naturforschung B, Volume 73, Issue 9, Pages 641–645, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-2018-0076.

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