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Zeitschrift für Naturforschung B

A Journal of Chemical Sciences

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Metal-free, air-promoted, radical-mediated arylation of benzoquinone with phenylhydrazines

Mohammad Hosein Sayahi / Samira Ansari
  • CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, I. R. Iran
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/ Seyyed Jafar Saghanezhad / Mohammad Mahdavi
  • Corresponding author
  • Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, I. R. Iran
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Published Online: 2018-09-11 | DOI: https://doi.org/10.1515/znb-2018-0081


An efficient, economic, and air-promoted metal-free method for direct arylation of benzoquinone with phenylhydrazines was developed. This approach leads to the formation of corresponding [1,1′-biphenyl]-2,5-dione derivatives as biological and pharmaceutical materials of interest in good yields, under mild reaction conditions, and at ambient temperature.

This article offers supplementary material which is provided at the end of the article.

Keywords: [1,1′-biphenyl]-2,5-dione; benzoquinone; cross-coupling reaction; direct arylation; phenylhydrazine


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About the article

Received: 2018-04-29

Accepted: 2018-08-10

Published Online: 2018-09-11

Citation Information: Zeitschrift für Naturforschung B, 20180081, ISSN (Online) 1865-7117, ISSN (Print) 0932-0776, DOI: https://doi.org/10.1515/znb-2018-0081.

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