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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Effect of Alkali Chlorides on Human Chromosomes Studied by the Method of Poly-L-lysine Binding

  • S. P. Marfey and M. G. Li

Abstract

Human metaphase chromosomes A1 and A3 did bind more tritiated poly-L-lysine ([3H]PL) when they were isolated from lymphocyte cultures treated with LiCl rather than with NaCl or KCl. A2 chromosome did not show this differential behavior and in all three cases did bind more [3H] PL than the control A2 chromosome. The effect was dependent on the time of exposure of cells to the salts in tissue culture and on the degree of chromosomal contraction. The observed differences in [3H] PL binding are probably due to differences in surface morphology of the three chromosomes caused by treatment with alkali metal salts

Received: 1974-10-21
Published Online: 2014-6-2
Published in Print: 1975-4-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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