Reductions with [3H]NaBH4 proof that the decrease in viscosity of hyaluronic acid solutions caused by lowering the pH does not depend on a depolymerisation of hyaluronic acid. At the same time investigations at different pH-values, show a sigmoide increase of the Spin-Lattice-Relaxationtime T1. This increase depends on a progressive aggregation of the hyaluronic acid molecule. The effect seems to be induced by the decrease of ionization of the carboxylgroups, by acidification of the solution.
Keywords: Spin-Lattice-Relaxationtime T1; Hyaluronicacid; Methylhyaluronate; Dipol-Dipol-Relaxationmechanism; Aggregation
Received: 1979-2-16
Revised: 1979-3-21
Published Online: 2014-6-2
Published in Print: 1979-8-1
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