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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

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1865-7125
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Volume 37, Issue 10

Issues

The Reversibility of the Vitamin C Redox System: Electrochemical Reasons and Biological Aspects

Helmut Sapper
  • Institut für Biophysik der Justus-Liebig-Universität Gießen, Leihgestemer Weg 217, D-6300 Gießen
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sa-Ouk Institut für Biophysik der Justus-Liebig-Universität Gießen, Leihgestemer Weg 217, D-6300 Gießen / Hans-Helmut Paul
  • Institut für Biophysik der Justus-Liebig-Universität Gießen, Leihgestemer Weg 217, D-6300 Gießen
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Wolfgang Lohmann
  • Institut für Biophysik der Justus-Liebig-Universität Gießen, Leihgestemer Weg 217, D-6300 Gießen
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-1982-1015

Abstract

The biological efficacy of vitamin C depends on its redox abilities as given by the relations between ascorbic acid, semidehydroascorbic acid, and dehydroascorbic acid. It is shown by means of proton magnetic resonance spectroscopy that the enzymatic (by ascorbate oxidase) as well as non-enzymatic (by iodine) oxidation of ascorbic acid is, in principle, reversible despite the hydration and structural changes during the formation of dehydroascorbic acid. The strong redox activity of semidehydroascorbic acid which results in a fast disproportionation to ascorbic acid and dehydroascorbic acid is inferred from an inversion of the electrochemical potentials of the vitamin C redox system. The capacity of this is maintained by a fast reduction of dehydro­ ascorbic acid e.g. by reduced glutathione, preventing its delactonization and further degradation.

Keywords: Vitamin C; Dehydroascorbic Acid; Glutathione; Ascorbate Oxidase; NMR Spectroscopy

About the article

Received: 1982-05-19

Revised: 1982-07-20

Published Online: 2014-06-02

Published in Print: 1982-10-01


Citation Information: Zeitschrift für Naturforschung C, Volume 37, Issue 10, Pages 942–946, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-1982-1015.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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[1]
I Yamazaki, M Tamura, R Nakajima, and M Nakamura
Environmental Health Perspectives, 1985, Volume 64, Page 331

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