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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

12 Issues per year


IMPACT FACTOR 2016: 0.835

CiteScore 2016: 0.72

SCImago Journal Rank (SJR) 2016: 0.222
Source Normalized Impact per Paper (SNIP) 2016: 0.413

Online
ISSN
1865-7125
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Volume 38, Issue 3-4

Issues

Enhancement of in-vitro Translation of Eukaryotic RNAs by Cyclic AMP

M. E. John
  • Institut für Molekularbiologie und Biochemie, FB I, WE3, Freie Universität Berlin, Arnimallee 22, D-1000 Berlin 33
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ W. Knöchel
  • Institut für Molekularbiologie und Biochemie, FB I, WE3, Freie Universität Berlin, Arnimallee 22, D-1000 Berlin 33
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-1983-3-419

Addition of cyclic AMP to normal rabbit reticulocyte lysate brings about substantial increase in protein synthesis programmed by both nuclear and polysomal eukaryotic RNAs. The increase in synthesis is largely nonspecific and the in-vitro translation system is rendered viable for longer periods of time than in the absence of cyclic AMP. This stimulation of translation could be due to the inhibition of protein kinases that are initially activated by secondary structure of RNAs. However, the ability of cyclic AMP to further stimulate methyl mercury or heat denatured RNA indicates that additional mechanisms may be involved in the enhancement of translation

: RNA; in-vitro Translation; Cyclic AMP; Double Stranded RNA; Protein Products

About the article

Received: 1982-11-23

Revised: 1982-09-22

Published Online: 2014-06-02

Published in Print: 1983-04-01


Citation Information: Zeitschrift für Naturforschung C, Volume 38, Issue 3-4, Pages 277–281, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-1983-3-419.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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