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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

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Volume 45, Issue 3-4


X-Ray and Fluorescence Studies on Phospholipid Bilayers. IX. Interactions with Pentachlorophenol

M. Suwalsky / M. A. Espinoza / M. Bagnara / C. P. Sotomayor
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-1990-3-421


Pentachlorophenol (PCP) is a widely used and highly toxic fungicide. Its toxicity is mainly expressed at the cell membrane level. It is, therefore, of interest to test its ability to alter the lipid bilayer organization. The present study was performed by X-ray diffraction techniques on dimyristoylphosphatidylethanolamine (DMPE) and dimyristoylphosphatidylcholine (DMPC) bilayers and by fluorescence on DMPC liposomes. These two phospholipids are respectively found at the inner and outer monolayers of human erythrocyte membranes. Each type of phospholipid was made to interact with different concentrations of the sodium form of PCP in absence and in presence of water. It was found that PCP significatively affected the structure of both phospholipids, being the damage much higher in DM PC bilayers.

Keywords: X -R ay Diffraction; Fluorescence; Phospholipid Bilayers; Pentachlorophenol; Toxicity

About the article

Received: 1989-09-18

Published Online: 2014-06-02

Published in Print: 1990-04-01

Citation Information: Zeitschrift für Naturforschung C, Volume 45, Issue 3-4, Pages 265–272, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-1990-3-421.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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