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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

12 Issues per year

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5-year IMPACT FACTOR: 0.912

CiteScore 2017: 0.92

SCImago Journal Rank (SJR) 2017: 0.288
Source Normalized Impact per Paper (SNIP) 2017: 0.448

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Volume 47, Issue 5-6


Renaissance for Hapten-Specific T Lymphocytes: Implications for Basic and Applied Research

Hans Ulrich
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-1992-0601

Protein-reactive chemicals and drugs (haptens), such as dinitro- (DNP) or trinitro-phenylated (TNP) reagents or penicillins, are potent inducers of allergic reactions in experimental animal systems as well as in humans. Hapten-specific T lymphocytes are mediators of these disorders. Like other antigens, hapten determinants on target cells are recognized by the T cell’s antigen-specific receptors exclusively in association with gene products of the major histocompatibility complex (MHC). Until recently, the nature of the complex hapten/MHC determinants remained unknown. Atypically, this fact, rather than spurring scientific investigations, caused a rapid loss of interest in haptens as T cell antigens by the majority of immunologists. This situation may now be changing, since we have recently identified MHC-binding, haptenmodified peptides which mediate cellular recognition by T cells via their antigen-specific receptors. Synthetic hapten-peptide conjugates open up new routes in studying the molecular details of hapten recognition by T cells. They may also contribute to a better understanding of what defines an antigen as an allergy-inducing “allergen”.

About the article

Received: 1992-02-14

Published Online: 2014-06-02

Published in Print: 1992-06-01

Citation Information: Zeitschrift für Naturforschung C, Volume 47, Issue 5-6, Pages 323–328, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-1992-0601.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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