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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Physiological and Hemolytic Toxicity of Some Aminophosphonates

  • Zenon Trela , Halina Kleszczyńska and Janusz Sarapuk EMAIL logo

Abstract

The effect of novel synthesized aminophosphonates on membrane potential and electrical conductance of internodal cells of Nitellopsis obtusa and hemolysis of erythrocytes (RBC) was studied. It was found that those the organophosphorous compounds, when present at 10-100 μm concentrations, caused depolarization and increased electrical conductance of alga membranes. They also influenced fluidity of erythrocyte membranes. When used at higher concentrations aminophosphonates caused hemolysis of RBC. The changes observed depended on structural features of the aminophosphonates, i.e., substituents at the carbon, phosphorus and nitrogen atoms, and, most probably, may be the result of direct interaction of the am inophosphonates with the lipid phase of the plasma membrane and the induced structural changes. Two modes of interaction are proposed.

Received: 2001-4-18
Revised: 2001-5-30
Published Online: 2014-6-2
Published in Print: 2001-10-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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