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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2017: 0.882
5-year IMPACT FACTOR: 0.912

CiteScore 2017: 0.92

SCImago Journal Rank (SJR) 2017: 0.288
Source Normalized Impact per Paper (SNIP) 2017: 0.448

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1865-7125
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Volume 58, Issue 3-4

Issues

Investigation of the Immunostimulatory Properties of Oxihumate

Gisela Käthe Jooné
  • Department of Pharmacology, Faculty of Medical Sciences, University of Pretoria, PO Box 2034, Pretoria, 0001, South Africa
  • Other articles by this author:
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/ Johan Dekker / Constance Elizabeth Jansen van Rensburg
  • Corresponding author
  • Department of Pharmacology, Faculty of Medical Sciences, University of Pretoria, PO Box 2034, Pretoria, 0001, South Africa
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2003-3-421

A unique process has been developed to convert bituminous coal by controlled wet oxidation followed by base treatment to a water-soluble humate called oxihumate. The effects of oxihumate on the proliferative response of lymphocytes has been studied in vitro and ex vivo. Oxihumate increased the proliferative response of phytohaemagglutinin-stimulated human lymphocytes, from a concentration of 20 μg/ml and upwards. This response was even more striking in the case of lymphocytes from HIV-infected patients and was not limited to the in vitro setting since similar effects were observed ex vivo following administration of a nontoxic dosage of 4 g oxihumate per day to HIV-positive individuals for two weeks. Mechanistic studies revealed that stimulation of the proliferative response of lymphocytes by oxihumate is associated with an increased production of IL-2, as well as expression of the IL-2 receptor in the setting of decreased production of IL-10. Oxihumate therefore holds promise for the treatment of immunocompromized patients.

Keywords : Oxihumate; Immunostimulation; IL-2

About the article

Received: 2002-09-10

Revised: 2002-10-22

Published Online: 2014-06-02

Published in Print: 2003-04-01


Citation Information: Zeitschrift für Naturforschung C, Volume 58, Issue 3-4, Pages 263–267, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2003-3-421.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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