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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


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1865-7125
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Volume 58, Issue 3-4

Issues

Effect of CDP-choline on Hippocampal Acetylcholinesterase and Na+,K+-ATPase in Adult and Aged Rats

Christos Plataras
  • Department of Experimental Physiology, Medical School, University of Athens, P. O. Box 65257, GR-154 01 Athens, Greece
  • Other articles by this author:
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/ Panagoula Angelogianni
  • Department of Experimental Physiology, Medical School, University of Athens, P. O. Box 65257, GR-154 01 Athens, Greece
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stylianos Tsakiris
  • Corresponding author
  • Department of Experimental Physiology, Medical School, University of Athens, P. O. Box 65257, GR-154 01 Athens, Greece
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2003-3-423

The aim of this study was to investigate the effect of different cytidine-5′-diphosphocholine (CDP-choline) concentrations (0.1-1 mm) on acetylcholinesterase (AChE), (Na+,K+)-ATPase and Mg2+-ATPase activities in homogenates of adult and aged rat hippocampi. Tissues were homogenised, centrifuged at 1000 × g for 10 min and in the supernatant, AChE activity and Na+,K+-ATPase and Mg2+-ATPase activities were determined according to Ellman’s method and Bowler’s and Tirri’s method, respectively. After an 1-3 h preincubation of the homogenised tissue with CDP-choline, a maximal AChE stimulation of about 25% for both adult and aged rats (p < 0.001) and a Na+,K+-ATPase activation of about 50% for adult rats (p < 0.001) and about 60% for aged rats (p < 0.001) were observed, while hippocampal Mg2+- ATPase activity was not influenced in either adult or aged animals. It is suggested that: CDP-choline can restore hippocampal AChE and Na+,K+-ATPase activities in the aged rat and thus it may play a role in improving memory performance which is impaired by aging and some neuronal disturbances.

Keywords : Rat Hippocampal Acetylcholinesterase; Rat Hippocampal Na+,K+-ATPase; CDP-choline

About the article

Received: 2002-10-15

Revised: 2002-11-11

Published Online: 2014-06-02

Published in Print: 2003-04-01


Citation Information: Zeitschrift für Naturforschung C, Volume 58, Issue 3-4, Pages 277–281, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2003-3-423.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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