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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Anti-ulcerogenic Lignans from Taxus baccata L.

  • Ilhan Gurbuz , Nurgun Erdemoglu , Erdem Yesilada EMAIL logo and Bilge Sener

Four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-isolariciresinol, were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-ulcerogenic potency of these compounds was investigated on ethanol-induced ulcerogenesis model in rats at two different doses, 50 and 100 mg/kg. All compounds were shown to possess significant anti-ulcerogenic activity at both doses. However, the effect of taxiresinol was the most prominent.

Received: 2003-11-11
Revised: 2003-11-11
Published Online: 2014-6-2
Published in Print: 2004-4-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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