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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

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1865-7125
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Volume 59, Issue 5-6

Issues

Liposomal Formulations from Phospholipids of Greek Almond Oil. Properties and Biological Activity

Fotini Malisiova
  • School of Pharmacy, Department of Pharmaceutical Technology, University of Athens, Panepistimiopolis,15771, Athens, Greece
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/ Sophia Hatziantoniou
  • School of Pharmacy, Department of Pharmaceutical Technology, University of Athens, Panepistimiopolis,15771, Athens, Greece
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/ Kostas Dimas
  • IIBEAA, Basic Research, Laboratory of Pharmacology and Pharmacotechnology, S. Efesiou 4, 11527, Athens, Greece
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/ Dimitrios Kletstas
  • Laboratory of Cell Proliferation and Ageing, Institute of Biology, N. C. S. R. Demokritos, 15310, Athens, Greece
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/ Costas Demetzos
  • School of Pharmacy, Department of Pharmaceutical Technology, University of Athens, Panepistimiopolis,15771, Athens, Greece
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2004-5-607

The seeds of the almond tree [(Prunus dulcis (Mill.) D. A. Webb. (syn. Prunus amygdalus)] were collected in two different periods of maturity and were studied for their lipid content. The total lipids (TL) were extracted by the Bligh-Dyer method and the lipid classes have been isolated by chromatographic techniques and were analyzed by HPTLC coupled with a flame ionization detector (HPTLC/FID) and GC-MS. The oils were found to be rich in neutral lipids (89.9% and 96.3% of total lipids) and low in polar lipids (10.1% and 3.7% of total lipids) for the immature and mature seed oils, respectively. The neutral lipid fraction consisted mainly of triacylglycerides whereas the polar lipids mainly consisted of phospholipids. GC-MS data showed that the main fatty acid for both oils was 9-octadecenoic acid (oleic acid). The unsaturated fatty acids were found as high as 89.4% and 89.7%, while the percentage of the saturated fatty acids was found 10.6% and 10.3% for the immature and mature seed oils, respectively. Liposomes were prepared from the isolated phospholipids using the thin lipid film methodology, and their physical properties were characterized. Cytotoxicity was found absent when assayed against normal and cancerous cell lines. These new formulations may have future applications for encapsulation and delivery of drugs and cosmetically active ingredients.

Keywords : Almond Oil; Prunus dulcis; Liposomes

About the article

Received: 2004-01-14

Revised: 2004-02-12

Published Online: 2014-06-02

Published in Print: 2004-06-01


Citation Information: Zeitschrift für Naturforschung C, Volume 59, Issue 5-6, Pages 330–334, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2004-5-607.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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