Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

12 Issues per year


IMPACT FACTOR 2017: 0.882
5-year IMPACT FACTOR: 0.912

CiteScore 2017: 0.92

SCImago Journal Rank (SJR) 2017: 0.288
Source Normalized Impact per Paper (SNIP) 2017: 0.448

Online
ISSN
1865-7125
See all formats and pricing
More options …
Volume 59, Issue 5-6

Issues

Free Radical Scavengers and Antioxidants from Tagetes mendocina

Guillermo Schmeda-Hirschmann
  • Universidad de Talca, Instituto de Química de Recursos Naturales, Laboratorio de Productos Naturales, Casilla 747, Talca, Chile
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Alejandro Tapia
  • Universidad de Talca, Instituto de Química de Recursos Naturales, Laboratorio de Productos Naturales, Casilla 747, Talca, Chile
  • Universitat de Barcelona, Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmacia, Barcelona, España
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Cristina Theoduloz
  • Universidad de Talca, Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Casilla 747, Talca, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jaime Rodríguez
  • Universidad de Talca, Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Casilla 747, Talca, Chile
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Susana López
  • Universitat de Barcelona, Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmacia, Barcelona, España
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gabriela Egly Feresin
  • Universitat de Barcelona, Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmacia, Barcelona, España
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2004-5-610

Tagetes mendocina (Asteraceae) is a medicinal plant widely used in the Andean provinces of Argentina. Preliminary assays showed free radical scavenging activity in the methanol extract of the aerial parts, measured by the decoloration of a methanolic solution of the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and scavenging of the superoxide anion. Assayguided isolation led to 4′-hydroxyacetophenone (1), protocatechuic acid (2), syringic acid (3), patuletin (4), quercetagetin 7-O-β-d-glucoside (5), patuletin 7-O-β-d-glucoside (6) and axillarin 7-O-β-d-glucoside (7) as the free radical scavengers and antioxidant compounds from Tagetes mendocina. On the basis of dry starting material, the total phenolic content of the crude drug was 3.00% with 0.372% of flavonoids. The content of compounds 1-7 in the crude drug was 0.008, 0.015, 0.010, 0.029, 0.238, 0.058 and 0.017%, respectively. Quercetagetin 7-O-β-d-glucoside proved to be the main free radical scavenger of the extracts measured by the DPPH decoloration test as well as for quenching the superoxide anion and inhibition of lipoperoxidation in erythrocytes. In the lipid peroxidation assay the percentual inhibition was related with the number of methoxy groups in the molecule, ranging from 86% for the quercetagetin glucoside to 67% for the monomethoxylated and 31% for the dimethoxylated derivative. The compounds showed low cytotoxicity towards human lung fibroblasts with IC50 > 1mᴍ for compounds 1-3 and 0.24 to 0.52 mm for the flavonoids 4-7.

Keywords: Tagetes mendocina; Phenolics; Antioxidant Activity

About the article

Received: 2003-09-08

Revised: 2003-11-19

Published Online: 2014-06-02

Published in Print: 2004-06-01


Citation Information: Zeitschrift für Naturforschung C, Volume 59, Issue 5-6, Pages 345–353, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2004-5-610.

Export Citation

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Letícia Maria Krzyzaniak, Tânia Mara Antonelli-Ushirobira, Gean Panizzon, Ana Luiza Sereia, José Roberto Pinto de Souza, João Antonio Cyrino Zequi, Cláudio Roberto Novello, Gisely Cristiny Lopes, Daniela Cristina de Medeiros, Denise Brentan Silva, Eneri Vieira de Souza Leite-Mello, and João Carlos Palazzo de Mello
Evidence-Based Complementary and Alternative Medicine, 2017, Volume 2017, Page 1
[2]
Cintia Mariana Romero, Cristian Germán Vivacqua, María Belén Abdulhamid, Mario Domingo Baigori, Alberto Carlos Slanis, María Cristina Gaudioso de Allori, and María Laura Tereschuk
Revista da Sociedade Brasileira de Medicina Tropical, 2016, Volume 49, Number 6, Page 703

Comments (0)

Please log in or register to comment.
Log in