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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

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1865-7125
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Volume 59, Issue 7-8

Issues

Complement Inhibiting Properties of Dragon’s Blood from Croton draco

Ivanka Tsacheva
  • Department of Biochemistry, Faculty of Biology, Sofia University, 8 Dragan Tsankov St., 1164 Sofia, Bulgaria. Fax: +359-2-865-6641
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/ Joerg Rostan / Tania Iossifova
  • Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
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/ Bernhard Vogler / Mariela Odjakova
  • Department of Biochemistry, Faculty of Biology, Sofia University, 8 Dragan Tsankov St., 1164 Sofia, Bulgaria. Fax: +359-2-865-6641
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/ Hernan Navas / Ivanka Kostova
  • Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
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/ Michaela Kojouharova
  • Corresponding author
  • Department of Biochemistry, Faculty of Biology, Sofia University, 8 Dragan Tsankov St., 1164 Sofia, Bulgaria. Fax: +359-2-865-6641
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/ Wolfgang Kraus
  • Department of Biochemistry, Faculty of Biology, Sofia University, 8 Dragan Tsankov St., 1164 Sofia, Bulgaria. Fax: +359-2-865-6641
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2004-7-814

Abstract

The latex of Croton draco, its extracts and several latex components have been investigated for their influence on both classical (CP) and alternative (AP) activation pathways of the complement system using a hemolytic assay. The best inhibition was found for the classical pathway. The latex, ethyl acetate and ethyl ether extracts exhibited extremely high inhibition on the CP (94, 90 and 77%, respectively) at a concentration of 1 mg/ml. The flavonoid myricitrin, the alkaloid taspine and the cyclopeptides P1 and P2 showed high inhibition on CP (83, 91, 78 and 63%, respectively) at a concentration of 0.9 mм.

Keywords: Croton draco; Components; Classical and Alternative Pathways Inhibition

About the article

Received: 2004-02-13

Revised: 2004-04-28

Published Online: 2014-06-02

Published in Print: 2004-08-01


Citation Information: Zeitschrift für Naturforschung C, Volume 59, Issue 7-8, Pages 528–532, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2004-7-814.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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