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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

Online
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1865-7125
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Volume 61, Issue 3-4

Issues

Anti-Inflammatory Activity of Two Diterpenes of Hyptis suaveolens from El Salvador

Paolo Grassi
  • Institute for Applied Botany, University of Veterinary Medicine, Veterinärplatz 1, A-1210 Vienna, Austria.
  • Other articles by this author:
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/ Tomás S. Urías Reyes
  • Facultad de Química y Farmacia-Biología, Universidad Salvadoreña Alberto Masferrer - USAM, 19a Avenida Norte entre 3a Calle Poniente y Alameda Juan Pablo II, San Salvador, El Salvador, C.A.
  • Other articles by this author:
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/ Silvio Sosa
  • Dipartimento dei Materiali e delle Risorse Naturali, Università di Trieste, Via Valerio 6, I-34127 Trieste, Italy
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/ Aurelia Tubaro
  • Dipartimento dei Materiali e delle Risorse Naturali, Università di Trieste, Via Valerio 6, I-34127 Trieste, Italy
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/ Otmar Hofer
  • Institute of Organic Chemistry, University of Vienna, Währingerstraße 38, A-1090 Vienna, Austria
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/ Karin Zitterl-Eglseer
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2006-3-402

Separation and isolation of the two main compounds suaveolol and methyl suaveolate from leaves of chichinguaste (Hyptis suaveolens Poit., Lamiaceae) could be achieved by means of repeated column chromatography and repeated preparative thin layer chromatography. Their chemical structures were approved by MS, 1H NMR, 13C NMR and 2D-NMR experiments. The anti-inflammatory activity of the two compounds was tested for the first time as inhibition of croton oil-induced dermatitis of the mouse ear. Suaveolol and methyl suaveolate showed nearly the same dose-dependent topical anti-inflammatory activity, only two to three times lower than that of the reference drug indomethacin. The anti-inflammatory properties of these compounds could contribute to the antiphlogistic activity of extracts of Hyptis species and confirm the rational use of Hyptis suaveolens extracts in dermatological diseases.

Keywords: Hyptis suaveolens; Diterpenes; Anti-Inflammatory Activity

About the article

Received: 2005-11-18

Revised: 2005-12-19

Published Online: 2014-06-02

Published in Print: 2006-04-01


Citation Information: Zeitschrift für Naturforschung C, Volume 61, Issue 3-4, Pages 165–170, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2006-3-402.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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