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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

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Volume 62, Issue 11-12


Antinociceptive and Anti-Inflammatory Effects of Saponin and Iridoid Glycosides from Verbascum pterocalycinum var. mutense Hub.-Mor.

Esra Küpeli Akkol
  • Corresponding author
  • Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler, 06330, Ankara, Turkey
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/ I. Irem Tatli
  • Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Sıhhiye, 06100, Ankara, Turkey
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/ Zeliha S. Akdemir
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2007-11-1207

The anti-inflammatory and antinociceptive properties of four major compounds from the flowers of Verbascum pterocalycinum var. mutense were investigated. Saponin glycosides called ilwensisaponin A and C and iridoid glycosides known as ajugol and picroside IV were isolated from the methanolic extract. A dose-related anti-inflammatory and antinociceptive response were obtained in this study at doses of 100 and 200 mg/kg. The results of the evaluation of the anti-inflammatory activity induced by carrageenan and PGE1 showed that this species possesses active constituents that could diminish the cyclooxygenase activitiy. No effects were observed in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model. Our results support the anti-inflammatory and analgesic effects of Verbascum pterocalycinum var. mutense. Ilwensisaponins A and C could explain in part the anti-inflammatory and analgesic activities of this species. Although antinociceptive and anti-inflammatory activities of ajugol and picroside IV were found insignificant in the statistical analysis, ilwensisaponin A and C showed notable activity without inducing any apparent acute toxicity as well as gastric damage.

Keywords: Verbascum pterocalycinum var. mutense; Anti-Inflammatory Activity; Antinociceptive Activity

About the article

Received: 2007-01-09

Revised: 2007-02-21

Published Online: 2014-06-02

Published in Print: 2007-12-01

Citation Information: Zeitschrift für Naturforschung C, Volume 62, Issue 11-12, Pages 813–820, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2007-11-1207.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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