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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

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1865-7125
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Volume 63, Issue 11-12

Issues

Identification of Ellagic Acid Derivatives in Methanolic Extracts from Qualea Species

Ana L. M. Nasser
  • Corresponding author
  • UNESP - São Paulo State University, Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP, Brazil. Fax: 55-16-33 01-66 92.
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/ Camila B. A. Carli
  • UNESP - São Paulo State University, Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP, Brazil
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/ Clenilson M. Rodrigues
  • UNESP - São Paulo State University, Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP, Brazil.
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/ Danielle C. G. Maia
  • UNESP - São Paulo State University, Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP, Brazil
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/ Iracilda Z. Carlos
  • UNESP - São Paulo State University, Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP, Brazil
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/ Marcos N. Eberlin / Clélia A. Hiruma-Lima
  • UNESP - São Paulo State University, Departamento de Farmacologia, Instituto de Biociências, 18618-000, Botucatu, SP, Brazil
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/ Wagner Vilegas
  • UNESP - São Paulo State University, Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP, Brazil. Fax: 55-16-33 01-66 92.
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2008-11-1203

Abstract

The methanolic extract from the barks of the medicinal plant Qualea parviflora (Vochysiaceae) was fractionated by column chromatography over silica gel followed by gel permeation over Sephadex LH-20 to give 3,3′-di-O-methylellagic acid-4-O-β-d-glucopyranoside (1), 3-Omethylellagic acid-4′-O-α-l-rhamnopyranoside (2), 3,3′,4-tri-O-methylellagic acid-4′-O-β-dglucopyranoside (3), and 3,3′-di-O-methylellagic acid (4), together with triterpenes and saponins. We also performed comparative analyses among this species and Q. grandiflora and Q. multiflora using high-pressure liquid chromatography. The biological assays showed that, when compared to the standard ellagic acid, compounds 1-4 are less cytotoxic but have a lower capacity of stimulating murine peritoneal macrophages to release nitric oxide and tumoural-α necrose factor.

Keywords: Qualea; Ellagic Acid Derivatives; Liquid Chromatography

About the article

Received: 2008-02-28

Revised: 2008-05-16

Published Online: 2014-06-02

Published in Print: 2008-12-01


Citation Information: Zeitschrift für Naturforschung C, Volume 63, Issue 11-12, Pages 794–800, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2008-11-1203.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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