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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

Online
ISSN
1865-7125
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Volume 63, Issue 11-12

Issues

Antinociceptive Activity and Preliminary Structure-Activity Relationship of Chalcone-Like Compounds

Rogério Corrêa
  • Corresponding author
  • Chemistry Department, Federal University of Santa Catarina (UFSC), 88049-000, Florianópolis, SC, Brazil / Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), University of Itajaí Valley (UNIVALI), 88302-202, Itajaí, SC, Brazil. Fax: + 47 334176 01.
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bruna Proiss Fenner
  • Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), University of Itajaí Valley (UNIVALI), 88302-202, Itajaí, SC, Brazil. Fax: + 47 334176 01.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Fátima de Campos Buzzi
  • Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), University of Itajaí Valley (UNIVALI), 88302-202, Itajaí, SC, Brazil. Fax: + 47 334176 01.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Valdir Cechinel Filho
  • Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), University of Itajaí Valley (UNIVALI), 88302-202, Itajaí, SC, Brazil. Fax: + 47 334176 01.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ricardo José Nunes
  • Chemistry Department, Federal University of Santa Catarina (UFSC), 88049-000, Florianópolis, SC, Brazil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2008-11-1208

Abstract

Chalcones belong to a class of α,β unsaturated aromatic ketones which occur abundantly in nature, especially in plants. They are promising and interesting compounds due to their vast applications in pharmaceuticals, agriculture and industry. Several studies have shown that these compounds exert important biological activities in different experimental models. The present work deals with the antinociceptive activity, evaluated against the writhing test, of three series of chalcone-like compounds obtained by the Claisen-Schmidt condensation, using different aldehydes and substituted acetophenones. The results reveal that the compounds synthesized show a significant antinociceptive effect compared with nonsteroidal drugs such as aspirin, paracetamol and diclofenac. They also show that the electronic demand of the substituents is the dominant factor of the biological activity.

Keywords: Chalcones; Claisen-Schmidt Reaction; Antinociceptive Activity

About the article

Received: 2008-04-16

Revised: 2008-06-04

Published Online: 2014-06-02

Published in Print: 2008-12-01


Citation Information: Zeitschrift für Naturforschung C, Volume 63, Issue 11-12, Pages 830–836, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2008-11-1208.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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