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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus

IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

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Volume 63, Issue 11-12


Fucoxanthin, Tetraprenylated Toluquinone and Toluhydroquinone Metabolites from Sargassum heterophyllum Inhibit the in vitro Growth of the Malaria Parasite Plasmodium falciparum

Anthonia F. Afolayan
  • Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown, 6140, South Africa. Fax: +274 6636 1205.
  • Other articles by this author:
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/ John J. Bolton / Carmen A. Lategan / Peter J. Smith / Denzil R. Beukes
  • Corresponding author
  • Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, Grahamstown, 6140, South Africa. Fax: +274 6636 1205. d.beukes@ru.ac.za
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2008-11-1211


In the course of our search for antimalarial leads from marine algae, four metabolites, sargaquinoic acid, sargahydroquinoic acid, sargaquinal and fucoxanthin, were isolated from the South African alga Sargassum heterophyllum. Fucoxanthin and sargaquinal showed good antiplasmodial activity toward a chloroquine-sensitive strain (D10) of Plasmodium falciparum (IC50 1.5 and 2.0 μm, respectively), while sargaquinoic acid and sargahydroquinoic acid were only moderately active (IC50 12.0 and 15.2 μm, respectively).

Keywords: Antiplasmodial Activity; Fucoxanthin; Sargaquinal

About the article

Received: 2008-07-16

Published Online: 2014-06-02

Published in Print: 2008-12-01

Citation Information: Zeitschrift für Naturforschung C, Volume 63, Issue 11-12, Pages 848–852, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2008-11-1211.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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