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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

Online
ISSN
1865-7125
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Volume 63, Issue 11-12

Issues

Increasing CoQ10 Production by Rhodopseudomonas palustris J001 Using a Two-Stage Fermentation Process

Shi-yun Jiang
  • Corresponding author
  • Institute of Resource Biology and Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China. Fax: +86278779 2265. /Department of Biotechnology, Guangxi University of Technology, Liuzhou 545006, P. R. China
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/ Long-jiang Yu
  • Institute of Resource Biology and Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China.
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2008-11-1217

Abstract

CoQ10 is used not only as a medicine but also as a food supplement due to its various physiological activities. The production of CoQ10 by microbes is a successful approach for generating large amounts of this natural product. The effects of dissolved oxygen (DO) contents and the two-stage fermentation process on cell growth and CoQ10 production by Rhodopseudomonas palustris J001 were investigated. The optimal DO contents for cell growth and CoQ10 production were 45% and 15%, respectively. A two-stage fermentation process, which consists of a 1st stage with 45% DO, a 2nd stage with 15% DO and a synchronous feeding of 2.0% NaAc at the switching time (42 h after inoculation), has proven to be the optimum fermentation process for the production of CoQ10. The maximum biomass, CoQ10 production and CoQ10 production rate were 1.31 g l-1, 89.1 mg l-1, and 1.142 mg l-1 h-1, respectively, increased by 28%, 585% and 426% as compared to the one-stage batch production with 45% DO. The DO level was the major factor to increase the CoQ10 production by the two-stage process.

: Keywords CoQ10; Rhodopseudomonas palustris; Two-Stage Process; Dissolved Oxygen

About the article

Received: 2008-04-21

Revised: 2008-07-02

Published Online: 2014-06-02

Published in Print: 2008-12-01


Citation Information: Zeitschrift für Naturforschung C, Volume 63, Issue 11-12, Pages 884–888, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2008-11-1217.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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