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BY-NC-ND 3.0 license Open Access Published by De Gruyter June 2, 2014

Anti-Hepatitis B Virus Activity of New Substituted Pyrimidine Acyclic Nucleoside Analogues

  • Adel A.-H. Abdel-Rahman EMAIL logo , Ibrahim F. Zeid , Hussien A. Barakat and Wael A. El-Sayed

A number of N-substituted pyrimidine acyclic nucleosides were synthesized by coupling reaction of 2-(2-chloroethoxy)ethyl acetate or (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate with the corresponding base followed by deprotection. The synthesized compounds were tested for their antiviral activity against hepatitis B virus (HBV). The plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with the synthesized compounds which showed moderate to high antiviral activities

Received: 2019-5-29
Revised: 2009-7-8
Published Online: 2014-6-2
Published in Print: 2009-12-1

© 1946 – 2014: Verlag der Zeitschrift für Naturforschung

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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