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Zeitschrift für Naturforschung C

A Journal of Biosciences

Editor-in-Chief: Seibel, Jürgen

Editorial Board: Aigner , Achim / Boland, Wilhelm / Bornscheuer, Uwe / Hoffmann, Klaus


IMPACT FACTOR 2018: 1.000

CiteScore 2018: 0.99

SCImago Journal Rank (SJR) 2018: 0.246
Source Normalized Impact per Paper (SNIP) 2018: 0.437

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1865-7125
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Volume 64, Issue 11-12

Issues

Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae)

Camila M. Oliveira
  • NuBBE – Núcleo de Bioensaios, Biossíntese e Ecofi siologia de Produtos Naturais, Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista, Rua Professor Francisco Degni, SN, Bairro Quitandinha, 14800-900 Araraquara, São Paulo, Brazil. Fax +55-16-33 22 79 32
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Geraldo H. Silva
  • Universidade Federal de Sergipe, Av. Vereador Olimpio Grande, SN, 49500-000 Itabaiana, Sergipe, Brazil
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/ Luis O. Regasini
  • NuBBE – Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista, Rua Professor Francisco Degni, SN, Bairro Quitandinha, 14800-900 Araraquara, São Paulo, Brazil. Fax +55-16-33 22 79 32
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/ Lisinéia M. Zanardi
  • NuBBE – Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista, Rua Professor Francisco Degni, SN, Bairro Quitandinha, 14800-900 Araraquara, São Paulo, Brazil. Fax +55-16-33 22 79 32
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/ Alana H. Evangelista
  • NuBBE – Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista, Rua Professor Francisco Degni, SN, Bairro Quitandinha, 14800-900 Araraquara, São Paulo, Brazil. Fax +55-16-33 22 79 32
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/ Maria C. M. Young
  • Seção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, Av. Miguel Stéfano 3687, 04301-902 São Paulo, São Paulo, Brazil
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/ Vanderlan S. Bolzani
  • NuBBE – Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista, Rua Professor Francisco Degni, SN, Bairro Quitandinha, 14800-900 Araraquara, São Paulo, Brazil. Fax +55-16-33 22 79 32
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/ Angela R. Araujo
  • Corresponding author
  • NuBBE – Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista, Rua Professor Francisco Degni, SN, Bairro Quitandinha, 14800-900 Araraquara, São Paulo, Brazil. Fax +55-16-33 22 79 32
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Published Online: 2014-06-02 | DOI: https://doi.org/10.1515/znc-2009-11-1212

In the course of our continuous search for bioactive metabolites from endophytic fungi living in plants from the Brazilian fl ora, leaves of Alibertia macrophylla (Rubiaceae) were submitted to isolation of endophytes, and two species of Penicillium were isolated. The acetonitrile fraction obtained in corn from a culture of Penicillium sp.1 afforded orcinol (1). On the other hand, Penicillium sp.1 cultivated in potato-dextrose-broth furnished two different compounds, cyclo-(L-Pro-L-Val) (2) and uracil (3). The chromatographic fractionation of the acetonitrile fraction obtained from Penicillium sp.2 led to three dihydroisocoumarins, 4-hydroxymellein (4), 8-methoxymellein (5) and 5-hydroxymellein (6). Compounds 5 and 6 were obtained from the Penicillium genus for the fi rst time. Additionally, metabolites 1 - 6 were evaluated for their antifungal and acetylcholinesterase (AChE) inhibitory activities. The most active compounds 1 and 4 exhibited detection limits of 5.00 and 10.0 μg against Cladosporium cladosporioides and C. sphaerospermum, respectively. Compound 2 showed a detection limit of 10.0 μg, displaying potent AChE inhibitory activity.

Keywords: Penicillium; Alibertia macrophylla; Endophytic Fungi; Acetylcholinesterase

About the article

Received: 2009-06-29

Published Online: 2014-06-02

Published in Print: 2009-12-01


Citation Information: Zeitschrift für Naturforschung C, Volume 64, Issue 11-12, Pages 824–830, ISSN (Online) 1865-7125, ISSN (Print) 0939-5075, DOI: https://doi.org/10.1515/znc-2009-11-1212.

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© 1946 – 2014: Verlag der Zeitschrift für Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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